1. Anti-infection
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. Antibiotic
    STAT
    Parasite
  3. Niclosamide sodium

Niclosamide sodium (Synonyms: BAY2353 sodium)

Cat. No.: HY-B0497A
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Niclosamide (BAY2353) sodium is an orally active antihelminthic agent used in parasitic infection research. Niclosamide sodium is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide sodium has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.

For research use only. We do not sell to patients.

Niclosamide sodium Chemical Structure

Niclosamide sodium Chemical Structure

CAS No. : 40321-86-6

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Description

Niclosamide (BAY2353) sodium is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide sodium is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide sodium has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

In Vitro

Niclosamide sodium (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].
Niclosamide sodium (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells[4].
Niclosamide sodium (10 μM) treatment inhibits virus replication in Vero E6 cells[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: BD140A, SW-13 and NCI-H295R cells
Concentration: 0.6 nM-46 µM
Incubation Time:
Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 µM, 0.15 µM, and 0.53 µM in BD140A, SW-13, and NCI-H295R, respectively.

Cell Viability Assay[4]

Cell Line: Hela cells
Concentration: 0.05-5 μM
Incubation Time: 24 hours
Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.

Western Blot Analysis[5]

Cell Line: Vero E6 cells
Concentration: 10 μM
Incubation Time: 2 days
Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
In Vivo

Niclosamide sodium (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nu+/Nu+ mice injected with NCI-H295R cells[3]
Dosage: 100 mg/kg, 200 mg/kg
Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
Molecular Weight

349.10

Formula

C13H7Cl2N2NaO4

CAS No.
SMILES

O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O[Na]

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Niclosamide sodium
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