IQTub4P 

IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC₅₀ of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo^[1].

IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells^[1].
IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM^[1].
IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest^[1].
IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IQTub4P (Balb/c mice, 25 mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

465.30

C₁₉H₁₈NNa₂O₈P

2376321-67-2

O=P(O[Na])(O[Na])OC1=CC2=C(C(C3=CC(OC)=C(C(OC)=C3)OC)=NC=C2)C=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kraus Y, Glas C, Melzer B, et al. Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors. Eur J Med Chem. 2020;186:111865.  [Content Brief]