IQTub4P
IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo.
For research use only. We do not sell to patients.
- CAS No.: 2376321-67-2
- Formula: C19H18NNa2O8P
- Molecular Weight:465.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
170 nM
Compound: IQTub4P
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Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by resazurin dye based fluorescence assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by resazurin dye based fluorescence assay
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[PMID: 31735573] |
| HL-60 | EC50 |
570 nM
Compound: IQTub4P
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Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth after 24 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth after 24 hrs by MTT assay
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[PMID: 31735573] |
IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells[1].
IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM[1].
IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest[1].
IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells[1]
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Concentration:
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Incubation Time:48 h
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Result:Showed strong dose-dependent cytotoxicity in HeLa cells, with EC50 of 170 nM, and displayed near-identical cytotoxicity in cell culture as its free phenol form IQTub4 (EC50 = 120 nM).
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Cell Line:HeLa cells[1]
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Concentration:0, 0.06, 0.12, 0.5, 0.75, 1.25 μM
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Incubation Time:24 h
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Result:Showed potent induction of G2/M arrest, and showed extensive G2/M-arrest from 500 nM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice (female)[1]
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Dosage:25 mg/kg
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Administration:IP and IV, 3 administration, 48 h intervals
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Result:Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32 mg/kg (i.p.) and 50 mg/kg (i.v.).
Chemical Information
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CAS No. 2376321-67-2
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Molecular Weight 465.30
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Formula C19H18NNa2O8P
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SMILES
O=P(O[Na])(O[Na])OC1=CC2=C(C(C3=CC(OC)=C(C(OC)=C3)OC)=NC=C2)C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IQTub4P Related Classifications
HY-146692 Related Classifications
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