1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. NMS-P515

NMS-P515 

Cat. No.: HY-128599
Handling Instructions

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity.

For research use only. We do not sell to patients.

NMS-P515 Chemical Structure

NMS-P515 Chemical Structure

CAS No. : 1262395-13-0

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Description

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity[1].

IC50 & Target[1]

PARP-1

16 nM (Kd)

PARP-1

27 nM (IC50, in Hela cells)

In Vivo

NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer[1].

Animal Model: Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts[1].
Dosage: 80 mg/kg.
Administration: Orally, once daily for 12 days.
Result: Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).
Molecular Weight

355.47

Formula

C₂₁H₂₉N₃O₂

CAS No.

1262395-13-0

SMILES

O=C(N)C1=C2C([[email protected]](C)N(C3CCN(C4CCCCC4)CC3)C2=O)=CC=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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