1. Apoptosis
  2. Caspase
    Apoptosis
  3. PETCM

PETCM 

Cat. No.: HY-103349 Purity: >99.0%
Handling Instructions

PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells.

For research use only. We do not sell to patients.

PETCM Chemical Structure

PETCM Chemical Structure

CAS No. : 10129-56-3

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10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells[1][2].

IC50 & Target[1]

Caspase 3

 

In Vitro

PETCM (0.1-0.5 mM) stimulates caspase-3 activity (DEVD activity) of HeLa S-100 in a dose-dependent manner.And 0.2 mM PETCM is more efficient in activating caspase-3 than 1 mM dATP[1].
PETCM (0.2 mM; 1 hour) drives apoptosome formation. Apaf-1 in a normal HeLa cell S-100 fraction is in an inactive monomeric form. After 1 mM dATP, most of the Apaf-1 shifted to a size of 1 million daltons. After the S-100 fraction with 0.2 mM PETCM, Apaf-1 exhibits a similar shift. And the efficiency of apoptosome formation was better with 0.2 mM PETCM[1].
PETCM (0.2 mM; 1 hour) can antagonize the inhibitory activity of ProT reduced caspase-3 activation in in HeLa cells[1].

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0.2 mM
Incubation Time: 1 hour
Result: Increased apoptosome formation.
Molecular Weight

240.51

Formula

C₈H₈Cl₃NO

CAS No.

10129-56-3

SMILES

OC(C(Cl)(Cl)Cl)CC1=CC=NC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

PETCMCaspaseApoptosisactivatorapaf-1helacellcancerapoptosisdevdInhibitorinhibitorinhibit

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