10129-56-3
10129-56-3
Chemical Structure
PETCM
- CAS No.: 10129-56-3
- Formula:C8H8Cl3NO
- Molecular Weight:240.51
IUPAC Name: 1,1,1-trichloro-3-(pyridin-4-yl)propan-2-ol
InChIKey: NGTDJJKTGRNNAU-UHFFFAOYSA-N
SMILES: OC(C(Cl)(Cl)Cl)CC1=CC=NC=C1
Biological Activity: PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells[1][2].
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PETCM | 99.68% | PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells. | ||||||||||||||||||||
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PETCM (Standard) | ≥98% | PETCM (Standard) is the analytical standard of PETCM (HY-103349). This product is intended for research and analytical applications. PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells. | ||||||||||||||||||||
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References
- [1]. Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. [Content Brief]
- [2]. .Jiang X, Kim HE, Shu H, et al. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science, 2003, 299(5604): 223-226. [Content Brief]
Keywords
