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Cat. No.: HY-157419

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FL77-24

(Synonyms: 7-(4-Ethylphenyl)-FL118)

FL77-24, a FL118 analog and apoptosis inducer, possesses antitumor activity, with IC₅₀ values of 99.4 nM, 118 nM, <6.4 nM, 28.5 nM and <6.4 nM in HCT116, HepG2, MCF-7, A549 and HeLa cells, respectively. FL77-24 mainly causes cell cycle arrest in S and G2/M phases.

For research use only. We do not sell to patients.

CAS No.: 2413582-39-3
Formula: C₂₉H₂₄N₂O₈
Molecular Weight:528.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

FL77-24 Chemical Structure

CAS No.: 2413582-39-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	28.5 nM Compound: FL77-24	Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis	[PMID: 38100041]
HCT-116	IC₅₀	99.4 nM Compound: FL77-24	Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis	[PMID: 38100041]
HeLa	IC₅₀	<6.4 nM Compound: FL77-24	Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis	[PMID: 38100041]
HepG2	IC₅₀	118 nM Compound: FL77-24	Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis	[PMID: 38100041]
MCF7	IC₅₀	<6.4 nM Compound: FL77-24	Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis	[PMID: 38100041]

Chemical Information

CAS No. 2413582-39-3
Molecular Weight 528.51
Formula C₂₉H₂₄N₂O₈
SMILES

CC[C@]1(C(OCC2=C1C=C3C4=NC5=C(C(C6=CC(OC)=CC(OC)=C6)=C4CN3C2=O)C=C7OCOC7=C5)=O)O
Synonyms

7-(4-Ethylphenyl)-FL118
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wenchao Wang, et al. Structure-Activity Relationship of FL118 Platform Position 7 Versus Position 9-Derived Compounds and Their Mechanism of Action and Antitumor Activity. J Med Chem. 2023 Dec 28;66(24):16888-16916. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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