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Cat. No.: HY-N11636

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Ganoderic acid S

Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway.

For research use only. We do not sell to patients.

CAS No.: 103963-38-8
Formula: C₃₂H₄₈O₅
Molecular Weight:512.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Ganoderic acid S Chemical Structure

CAS No.: 103963-38-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	>98 μM Compound: 39	Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 26716912]

In Vitro

Ganoderic acid S (0, 39.1, 97.7 μM; 12 h) causes cell cycle arrest in the S phase in HeLa cells^[1].
Ganoderic acid S dose-dependently causes the collapse of mitochondrial membrane potential. Ganoderic acid S induces a substantial release of cytochrome c from the mitochondria into the cytosol in HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0, 39.1, 97.7 μM
Incubation Time:

12 h
Result:

Caused cell cycle arrest in the S phase.

Chemical Information

CAS No. 103963-38-8
Molecular Weight 512.72
Formula C₃₂H₄₈O₅
SMILES

C[C@@]12C3=CC[C@](C)([C@@](CC4)([H])[C@H](C)[C@@H](OC(C)=O)C/C=C(C)/C(O)=O)[C@]4(C)C3=CC[C@@]1([H])C(C)([C@@H](CC2)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Microorganisms
Ganoderma lucidum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu RM, et al. Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine. 2011 Mar 15;18(5):349-55. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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