Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642

  • J Nat Prod. 2016 Jan 22;79(1):161-9. doi: 10.1021/acs.jnatprod.5b00826.
Masahiko Isaka  1 ,  Panida Chinthanom  1 ,  Malipan Sappan  1 ,  Kannawat Danwisetkanjana  1 ,  Thitiya Boonpratuang  1 ,  Rattaket Choeyklin  2
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology (BIOTEC) , 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
  • 2. Biodiversity-Based Economy Development Office, The Government Complex , Chaeng Wattana Road, Bangkok 10210, Thailand.
PMID: 26716912 DOI: 10.1021/acs.jnatprod.5b00826
Abstract

Sixteen new lanostane triterpenoids (1-16), together with 26 known compounds (17-42), were isolated from cultures of the basidiomycete Ganoderma sp. BCC 16642. Antitubercular activities of these Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated, and structure-activity relationships are proposed.

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