KKL-40
Based on 1 Customer Validation
KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells.
For research use only. We do not sell to patients.
- Purity: 95.70%
- CAS No.: 865285-47-8
- Formula: C16H9F4N3O2
- Molecular Weight:351.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
29 μM
Compound: 32
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Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay
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[PMID: 30472604] |
| HEK293 | IC50 |
5 μM
Compound: 32
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Inhibition of human AC1 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay
Inhibition of human AC1 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay
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[PMID: 30472604] |
Chemical Information
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CAS No. 865285-47-8
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Appearance Solid
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Molecular Weight 351.26
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Formula C16H9F4N3O2
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Color White to off-white
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SMILES
O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)C3=CC=CC(C(F)(F)F)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (71.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8469 mL | 14.2345 mL | 28.4689 mL | 71.1723 mL |
| 5 mM | 0.5694 mL | 2.8469 mL | 5.6938 mL | 14.2345 mL | |
| 10 mM | 0.2847 mL | 1.4234 mL | 2.8469 mL | 7.1172 mL | |
| 15 mM | 0.1898 mL | 0.9490 mL | 1.8979 mL | 4.7448 mL | |
| 20 mM | 0.1423 mL | 0.7117 mL | 1.4234 mL | 3.5586 mL | |
| 25 mM | 0.1139 mL | 0.5694 mL | 1.1388 mL | 2.8469 mL | |
| 30 mM | 0.0949 mL | 0.4745 mL | 0.9490 mL | 2.3724 mL | |
| 40 mM | 0.0712 mL | 0.3559 mL | 0.7117 mL | 1.7793 mL | |
| 50 mM | 0.0569 mL | 0.2847 mL | 0.5694 mL | 1.4234 mL | |
| 60 mM | 0.0474 mL | 0.2372 mL | 0.4745 mL | 1.1862 mL |
KKL-40 Related Classifications
HY-116863 Related Classifications
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