2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species MMP Caspase
  4. Ganoderic acid Mk

Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research.

For research use only. We do not sell to patients.

Ganoderic acid Mk Chemical Structure

Ganoderic acid Mk Chemical Structure

CAS No. : 110024-14-1

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Ganoderic acid Mk Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research[1][2].

IC50 & Target

Caspase-3

 

Caspase-9

 

In Vitro

Ganoderic acid Mk (0-100 μM, 24 h) exhibits stronger cytotoxicity to human cancer cells than human normal cell lines[1].
Ganoderic acid Mk (0-40 μM, 12-48 h) has a dose-dependent inhibitory effect on proliferation of HeLa cells[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces HeLa cells apoptosis[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces ROS burst, MMP decrease and caspase-3, -9 activities increase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderic acid Mk Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human normal cell lines (MCF-10A and HF) and cancer cell lines (HO-8910PM, SW1990, 95-D and HeLa)
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Exhibited stronger cytotoxicity to human cancer cells (IC50 values were ranged within 29.8-44.2 µM) than human normal cell lines (IC50 values to MCF-10A and HF were 84.5 µM and 78.4 µM, respectively).

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20, 40 μM
Incubation Time: 12, 24, 48 h
Result: Showed cytotoxicity on HeLa cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 10, 20, 40 μM
Incubation Time: 24 h
Result: Increased the rate of early and late apoptotic cells in a dose-dependent manner in HeLa cells. GA-Mk could induce HeLa cells apoptosis in parallel with the accumulation of ROS, the loss of MMP and the activation of activities of caspases.
Molecular Weight

570.76

Formula

C34H50O7
CAS No.
SMILES

O=C(/C(C)=C/CC(C(C1CC([C@@]2(C)C3=CCC4[C@](C)(CCC(C4(C)C)OC(C)=O)C3=CC[C@]12C)O)C)OC(C)=O)O
Structure Classification
Initial Source

glossy ganoderma
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ganoderic acid Mk Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganoderic acid Mk110024-14-1GA-MkApoptosisReactive Oxygen SpeciesMMPCaspaseMatrix metalloproteinasesanti-proliferationHeLa cellsGanoderma lucidumMitochondriacervical cancerInhibitorinhibitorinhibit

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