Ganoderic acid Mk
Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research.
For research use only. We do not sell to patients.
- CAS No.: 110024-14-1
- Formula: C34H50O7
- Molecular Weight:570.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Caspase-3 |
Caspase-9 |
Ganoderic acid Mk (0-100 μM, 24 h) exhibits stronger cytotoxicity to human cancer cells than human normal cell lines[1].
Ganoderic acid Mk (0-40 μM, 12-48 h) has a dose-dependent inhibitory effect on proliferation of HeLa cells[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces HeLa cells apoptosis[1].
Ganoderic acid Mk (0-40 μM, 24 h) induces ROS burst, MMP decrease and caspase-3, -9 activities increase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human normal cell lines (MCF-10A and HF) and cancer cell lines (HO-8910PM, SW1990, 95-D and HeLa)
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Exhibited stronger cytotoxicity to human cancer cells (IC50 values were ranged within 29.8-44.2 µM) than human normal cell lines (IC50 values to MCF-10A and HF were 84.5 µM and 78.4 µM, respectively).
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Cell Line:HeLa cells
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Concentration:0, 5, 10, 20, 40 μM
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Incubation Time:12, 24, 48 h
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Result:Showed cytotoxicity on HeLa cells in a dose- and time-dependent manner.
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Cell Line:HeLa cells
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Concentration:0, 10, 20, 40 μM
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Incubation Time:24 h
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Result:Increased the rate of early and late apoptotic cells in a dose-dependent manner in HeLa cells. GA-Mk could induce HeLa cells apoptosis in parallel with the accumulation of ROS, the loss of MMP and the activation of activities of caspases.
Chemical Information
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CAS No. 110024-14-1
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Molecular Weight 570.76
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Formula C34H50O7
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SMILES
O=C(/C(C)=C/CC(C(C1CC([C@@]2(C)C3=CCC4[C@](C)(CCC(C4(C)C)OC(C)=O)C3=CC[C@]12C)O)C)OC(C)=O)O
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Synonyms
GA-Mk
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Structure Classification
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Initial Source
glossy ganoderma
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ganoderic acid Mk Related Classifications
HY-N11643 Related Classifications
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