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Cat. No.: HY-N13115

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21-Angeloyl-protoaescigenin

(Synonyms: (Z)-Protoescigenin 21-tiglate)

21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively.

For research use only. We do not sell to patients.

CAS No.: 35931-54-5
Formula: C₃₅H₅₆O₇
Molecular Weight:588.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

21-Angeloyl-protoaescigenin Chemical Structure

CAS No.: 35931-54-5

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	2.45 μM Compound: 25	Cytotoxicity against human A549 cells after 48 hrs by WST8 assay Cytotoxicity against human A549 cells after 48 hrs by WST8 assay	[PMID: 20371180]
MRC5	GI₅₀	18.11 μM Compound: 25	Cytotoxicity against human MRC5 cells after 48 hrs by WST8 assay Cytotoxicity against human MRC5 cells after 48 hrs by WST8 assay	[PMID: 20371180]
PANC-1	GI₅₀	11.86 μM Compound: 25	Cytotoxicity against human PANC1 cells after 48 hrs by WST8 assay Cytotoxicity against human PANC1 cells after 48 hrs by WST8 assay	[PMID: 20371180]
PC-3	GI₅₀	2.23 μM Compound: 25	Cytotoxicity against human PC3 cells after 48 hrs by WST8 assay Cytotoxicity against human PC3 cells after 48 hrs by WST8 assay	[PMID: 20371180]

Chemical Information

CAS No. 35931-54-5
Molecular Weight 588.81
Formula C₃₅H₅₆O₇
SMILES

OC[C@]12[C@](CC(C)([C@H]([C@@H]2O)OC(/C(C)=C\C)=O)C)([H])C3=CC[C@@]([C@@]4([C@@]([C@](C)([C@H](CC4)O)CO)([H])CC5)C)([H])[C@]5(C)[C@@]3(C[C@H]1O)C
Synonyms

(Z)-Protoescigenin 21-tiglate
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro[J]. RSC advances, 2019, 9(54): 31758-31772.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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References

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