2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Cytochrome P450 Reactive Oxygen Species (ROS) Apoptosis
  4. Antimycin A2

Antimycin A2 is a selective inhibitor of the cytochrome b-c1 complex in the mitochondrial electron transport chain. Antimycin A2 disrupts mitochondrial membrane potential and produces reactive oxygen species (ROS) by inhibiting electron transfer between cytochrome b and c. Antimycin A2 has bactericidal and piscicidal activity, as well as tumor cell growth inhibitory effects, and can induce S-phase cell cycle arrest and apoptosis in HeLa cells. Antimycin A2 is suitable for research of cervical cancer and fisheries management. Antimycin A2 can be naturally isolated from the fermentation products of Streptomyces sp. strains.

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Antimycin A2

Antimycin A2 Chemical Structure

CAS No. : 27220-57-1

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500 μg In-stock

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Based on 2 publication(s) in Google Scholar

Antimycin A2 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

Antimycin A2 is a selective inhibitor of the cytochrome b-c1 complex in the mitochondrial electron transport chain. Antimycin A2 disrupts mitochondrial membrane potential and produces reactive oxygen species (ROS) by inhibiting electron transfer between cytochrome b and c. Antimycin A2 has bactericidal and piscicidal activity, as well as tumor cell growth inhibitory effects, and can induce S-phase cell cycle arrest and apoptosis in HeLa cells. Antimycin A2 is suitable for research of cervical cancer and fisheries management. Antimycin A2 can be naturally isolated from the fermentation products of Streptomyces sp. strains[1].

In Vitro

Antimycin A2 (0.1-1.0 μg/mL; overnight incubation at 30°C) inhibits the growth of Saccharomyces cerevisiae Y-30, exhibiting the same fungicidal activity as the Antimycin A complex and its other major components (A1, A3, A4). The activity, corresponding to the diameter of the inhibition zone, of 82% (relative to the complex at 100%), and the actual minimum inhibitory concentration (m1) was 0.048-0.051 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimycin A2 Related Antibodies

Cell Viability Assay[1]

Cell Line: Saccharomyces cerevisiae Y-30
Concentration: 0.1-1.0 μg/mL
Incubation Time: 16 h
Result: Displayed the same fungicidal activity as the Antimycin A complex and other major components (A1, A3, A4) with the minimum inhibitory concentration ranging from 0.048 to 0.051 μg/mL.
The apparent difference in inhibition zone sizes was caused by its diffusion coefficient in agar rather than inherent biological activity.
In Vivo

In a model using common goldfish approximately 5 cm in length, Antimycin A2 (25, 50, 75 ppb; administered in water; single dose; observed until fish death) exhibits the same piscicidal activity as the Antimycin A complex and its other main components (A1, A3, A4), without significant differences in average time to death at each concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Common goldfish (5 cm in length) teleocidal activity evaluation model[1]
Dosage: 25 ppb (acetone), 50 ppb (acetone), 75 ppb (acetone)
Administration:
Result: Antimycin A2 showed equivalent teleocidal activity to the Antimycin A complex and other major components (A1, A3, A4) in common goldfish.
No significant differences in the mean death time of goldfish were detected among Antimycin A2, the complex, and other fractions at the tested concentrations, confirming that its fish-toxic potential was consistent with other components of the Antimycin A complex.
Molecular Weight

534.60

Formula

C27H38N2O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCC(O[C@H]([C@H]1CCCCCC)[C@H](C)OC([C@@H](NC(C2=CC=CC(NC=O)=C2O)=O)[C@@H](C)OC1=O)=O)=O
Structure Classification
Initial Source

Streptomyces species
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.0%

SDS (420 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References
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Antimycin A2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimycin A227220-57-1Antimycin A 2Antimycin A-2Cytochrome P450Reactive Oxygen Species (ROS)ApoptosisCYPsFungicideherbicideantifungalStreptomycesInhibitorinhibitorinhibit

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