2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. Poloxin-2

Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.

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Poloxin-2

Poloxin-2 Chemical Structure

CAS No. : 321695-37-8

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Poloxin-2 Related Antibodies

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Description

Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
15 μM
Compound: Poloxin-2
Induction of mitotic arrest in human HeLa cells by propidium iodide staining-based FACS analysis
Induction of mitotic arrest in human HeLa cells by propidium iodide staining-based FACS analysis
[PMID: 27425654]
HeLa IC50
10.5 μM
Compound: Poloxin-2
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37607438]
Molecular Weight

269.30

Formula

C16H15NO3
CAS No.
SMILES

O=C(C(C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Poloxin-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poloxin-2321695-37-8Poloxin2Poloxin 2Polo-like Kinase (PLK)Inhibitorinhibitorinhibit

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