321695-37-8
Chemical Structure
Poloxin-2
- CAS No.: 321695-37-8
- Formula:C16H15NO3
- Molecular Weight:269.30
IUPAC Name: (Z)-2,5-dimethyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dien-1-one
InChIKey: KWDBXGNIGYVOBI-VKAVYKQESA-N
SMILES: O=C(C(C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O
Biological Activity: Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.
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Poloxin-2 | Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins. | |||||||||||||||||||||
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Keywords
