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RGLS4326 sodium

(Synonyms: RG4326 sodium)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 sodium can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 sodium inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM.

For research use only. We do not sell to patients.

  • Purity: 99.67%
  • Molecular Weight:3082.42 (free acid)
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • RGLS4326 sodium Chemical Structure
    RGLS4326 sodium Chemical Structure
  • Experimental Validation Results for RGLS4326 sodium
  • Experimental Validation Results for RGLS4326 sodium
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • RGLS4326 sodium Chemical Structure
    RGLS4326 sodium Chemical Structure 5’-AsGsCmAfCfUfUmUsGs-3‘, sodium salt
    1/16
  • 1/16

    RGLS4326 sodium purchased from MedChemExpress. Usage Cited in: Patent. US20250283086A1.

    Customer Validation
     PC1 protein analysis in PPMO-treated WT9-7 cells. WT9-7 cells were incubated with PPMOs with the sequences corresponding to SEQ ID NO:47 (+604+628) in quadruplicate and a non-targeting control (NTC) for 2, 3 or 5 days. A non-targeting control (NTC) was used as a negative control and an inhibitor of miR-17 (RGLS4326), was included as a positive control.

  • 1/16

    RGLS4326 sodium purchased from MedChemExpress. Usage Cited in: Patent. US20250283086A1.

    Customer Validation
     Western blot images of PPMO-treated HEK293 cells. HEK293 cells were treated with PPMOs (+604+628) and (+611+635) with the sequences corresponding to SEQ ID NOs:47, and 334, respectively. A non-targeting control (NTC) was used as a negative control while an inhibitor of miR-17 (RGLS4326), was included as a positive control. PPMO-treated cells were harvested at 5 days and analysed for PC1 expression using western blot assay.

  • 5’-AsGsCmAfCfUfUmUsGs-3‘, sodium salt