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Cat. No.: HY-149354

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Aurora kinase-IN-4

Aurora kinase-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC₅₀: 1.7 nM). Aurora kinase-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC₅₀s of 4.27, 1.54, 3.08, 6.99 μM. Aurora kinase-IN-4 can be used for research of triple negative breast cancer (TNBC).

For research use only. We do not sell to patients.

CAS No.: 2877011-84-0
Formula: C₂₆H₂₈N₈O
Molecular Weight:468.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Aurora kinase-IN-4 Chemical Structure

CAS No.: 2877011-84-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Aurora Kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.08 μM Compound: 11c	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 37207533]
HeLa	IC₅₀	6.99 μM Compound: 11c	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 37207533]
L02	IC₅₀	23.39 μM Compound: 11c	Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 37207533]
MDA-MB-231	IC₅₀	1.54 μM Compound: 11c	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 37207533]
SJSA-1	IC₅₀	4.27 μM Compound: 11c	Antiproliferative activity against human SJSA-1 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human SJSA-1 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 37207533]

Chemical Information

CAS No. 2877011-84-0
Molecular Weight 468.55
Formula C₂₆H₂₈N₈O
SMILES

CN1CCN(C2=CC(N=C(C3=CC=C(NC(C=C)=O)C=C3)N=C4NC5=NNC(C)=C5)=C4C=C2)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Aurora kinase-IN-4

All Aurora Kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Aurora kinase-IN-4 Related Classifications

HY-149354 Related Classifications