2877011-84-0
2877011-84-0
Chemical Structure
Aurora kinase-IN-4
- CAS No.: 2877011-84-0
- Formula:C26H28N8O
- Molecular Weight:468.55
InChIKey: VXYSKFCQDLEGDW-UHFFFAOYSA-N
SMILES: CN1CCN(C2=CC(N=C(C3=CC=C(NC(C=C)=O)C=C3)N=C4NC5=NNC(C)=C5)=C4C=C2)CC1
Biological Activity: Aurora kinase-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora kinase-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora kinase-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
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Aurora kinase-IN-4 | Aurora kinase-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora kinase-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora kinase-IN-4 can be used for research of triple negative breast cancer (TNBC). | |||||||||||||||||||||
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References
Keywords
