2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK2-IN-19

JAK2-IN-19 (Compound 3p) is a JAK2 inhibitor with a KD value of 1.11 μM. JAK2-IN-19 inhibits the proliferation of K562 cells and HeLa cells. JAK2-IN-19 significantly reduces the level of p-JAK2. JAK2-IN-19 can be used for research on cervical cancer and leukemia.

For research use only. We do not sell to patients.

JAK2-IN-19

JAK2-IN-19 Chemical Structure

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JAK2-IN-19 Related Antibodies

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Description

JAK2-IN-19 (Compound 3p) is a JAK2 inhibitor with a KD value of 1.11 μM. JAK2-IN-19 inhibits the proliferation of K562 cells and HeLa cells. JAK2-IN-19 significantly reduces the level of p-JAK2. JAK2-IN-19 can be used for research on cervical cancer and leukemia[1].

IC50 & Target[1]

JAK2

1.11 μM (Kd)

Molecular Weight

543.33

Formula

C26H18BrF3N2O3
SMILES

O=C1[C@]2([C@]3(C(N(C)C4=CC=CC=C43)=O)N[C@@H](C(F)(F)F)[C@@H]2C5=CC=C(Br)C=C5)C6=CC=CC=C6O1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK2-IN-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK2-IN-19JAKJanus kinaseSpiro-pyrrolidine compoundCycloaddition reactionAntitumor activitiesMolecular dockingJAK2STAT3Surface plasmon resonance (SPR)Inhibitorinhibitorinhibit

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