2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Hsp90-IN-15

Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell.

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Hsp90-IN-15 Chemical Structure

Hsp90-IN-15 Chemical Structure

CAS No. : 2252283-32-0

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Hsp90-IN-15 Related Antibodies

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Description

Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell[1].

IC50 & Target

HSP90

 

In Vitro

Hsp90-IN-15 (compound 22g) againsts HeLa, HepG2, and MDA-MB-23 cells with IC50s of 19.6 μM, 16.1 μM, and 22.1 μM, respectively[1].
Hsp90-IN-15 binds with Hsp90N, and the △Tm value is 10.92 °C[1].
Hsp90-IN-15 (0-20 μM; 48 h) arrests cell cycle at S phase in a dose-dependent manner[1].
Hsp90-IN-15 (0-20 μM; 48 h) exhibits an accumulation of early and late apoptotic cells in a time and dose dependent manner[1].
Caspase-3 is an executioner caspase and modifies apoptosis proteins[1].
Hsp90-IN-15 (0-50 μM; 48 h) increases the expression of Bax and cleaved-caspase 3, as well as downregulates the levels of Bcl-2, pro-caspase 3 and Hsp90[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hsp90-IN-15 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Arrested cell cycle at S phase dose-dependently.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 48 hours
Result: Induced apoptosis in HeLa cells.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 12.5, 25, 50 μM
Incubation Time: 48 hours
Result: Decreased the level of Hsp90 and increased the proportion of Bax/Bcl-2 as well.
Molecular Weight

416.48

Formula

C23H27F3N4
CAS No.
SMILES

[H][C@@]12CCCN3CCC[C@@]([C@@]31[H])([C@]4(CCC5=C(C6=C(N=C5N4C2)C=CC(C(F)(F)F)=C6)N)[H])[H]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hsp90-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hsp90-IN-152252283-32-0HSPHeat shock proteinsL-shaped matrine derivativesanticancer activitytargeted modificationMDA-MB-231HepG2HeLaInhibitorinhibitorinhibit

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