Uzarigenin
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively.
For research use only. We do not sell to patients.
- CAS No.: 466-09-1
- Formula: C23H34O4
- Molecular Weight:374.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
3.9 μM
Compound: 1
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Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 32649211] |
| Calu-1 | IC50 |
8 μM
Compound: 23
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Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay
Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay
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[PMID: 30629433] |
| HeLa | IC50 |
3 μM
Compound: 23
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Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
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[PMID: 30629433] |
| Hs-578T | IC50 |
3.6 μM
Compound: 1
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Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 32649211] |
| MCF7 | IC50 |
6 μM
Compound: 23
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 30629433] |
| MDA-MB-231 | IC50 |
>30 μM
Compound: 1
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
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[PMID: 32649211] |
| PC-3 | IC50 |
0.3 μM
Compound: 23
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
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[PMID: 30629433] |
| U-251 | IC50 |
6 μM
Compound: 23
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Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay
Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay
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[PMID: 30629433] |
Chemical Information
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CAS No. 466-09-1
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Molecular Weight 374.51
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Formula C23H34O4
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SMILES
O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=C1
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Synonyms
NSC 119993; NSC 277290; Odorigeni
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Uzarigenin Related Classifications
HY-N1107 Related Classifications
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