Search Result

Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

tyrosine phosphatase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Phosphatase (144) PTEN (3) SHP1 (10) SHP2 (16) 5-HT Receptor (2) Acyltransferase (1) Akt (1) Aldose Reductase (1) Amyloid-β (1) Antibiotic (12) Apoptosis (18) Autophagy (3) Bacterial (14) Bcl-2 Family (1) Beta-secretase (1) Biochemical Assay Reagents (4) c-Met/HGFR (1) Caspase (1) COX (1) Cytochrome P450 (2) DNA/RNA Synthesis (1) EGFR (1) Enterovirus (1) ERK (6) Fluorescent Dye (3) Fungal (11) Glycosidase (4) Histone Methyltransferase (1) HIV Protease (2) IFNAR (1) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (1) Lipoxygenase (2) MAP3K (1) MAP4K (1) MDM-2/p53 (1) MHC (1) Monoamine Oxidase (2) NF-κB (2) Notch (1) p38 MAPK (1) Parasite (14) PD-1/PD-L1 (1) Phospholipase (2) PPAR (1) Pregnane X Receptor (PXR) (1) PROTACs (1) Ras (1) Reference Standards (9) Reverse Transcriptase (3) SARS-CoV (3) Sirtuin (3) Somatostatin Receptor (1) STAT (2) TGF-beta/Smad (1) Tie (3) TMV (1) Topoisomerase (3) Tyrosinase (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (6) Endocrinology (7) Infection (31) Inflammation/Immunology (23) Metabolic Disease (64) Neurological Disease (13)
Oligonucleotides:	Antisense Oligonucleotides (2)

168

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Phosphatase Btk Syk SHP2 PhosTACs PTEN Pyk2 TNK1 Tyrosine Hydroxylase DYRK BRK FAK SHP1 FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0852

Sodium orthovanadate 10+ Cited Publications	Phosphatase	Cancer
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

HY-B0537

Pentamidine 5+ Cited Publications MP-601205	Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite *Leishmania infantum* with an IC₅₀ of 2.5 μM. Pentamidine is a potent and selective *protein tyrosine* phosphatases (PTPases)** and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-B0537B

Pentamidine isethionate 5+ Cited Publications MP-601205 isethionate	Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite *Leishmania infantum* with an IC₅₀ of 2.5 μM. Pentamidine isethionate is a potent and selective *protein tyrosine* phosphatases (PTPases)** and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-100463

TPI-1 15+ Cited Publications	SHP1 Phosphatase	Inflammation/Immunology Cancer
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC₅₀ of 40 nM.

HY-116022A

4-Nitrophenyl phosphate disodium hexahydrate 2 Publications Verification p-Nitrophenyl phosphate disodium hexahydrate	Biochemical Assay Reagents	Others
4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .

HY-108547

Alexidine dihydrochloride 5 Publications Verification	Fungal Apoptosis	Infection Cancer
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .

HY-12219A

MSI-1436 lactate 5+ Cited Publications Trodusquemine lactate; Aminosterol-1436 lactate	Phosphatase	Endocrinology
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme *protein-tyrosine* phosphatase 1B (PTP1B), with an IC₅₀ of 1 μM, 200-fold preference over TCPTP (IC₅₀** of 224 μM).

HY-18756

NSC-87877 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Others
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits *dual-specificity phosphatase* 26 (DUSP26)** .

HY-W013478

PTP inhibitor 1	Phosphatase	Cancer
PTP inhibitor 1 is a *protein tyrosine* phosphatase (PTP)** inhibitor, with anti-angiogenic effect .

HY-N1549

Prunin 4 Publications Verification Naringenin 7-0-glucoside	Enterovirus Phosphatase	Infection Metabolic Disease
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 5.5 μM .

HY-116022

4-Nitrophenyl phosphate 3 Publications Verification p-Nitrophenyl phosphate	Biochemical Assay Reagents	Others
4-Nitrophenyl phosphate (p-Nitrophenyl phosphate) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases.4-Nitrophenyl phosphate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .

HY-13588

Cefsulodin sodium SCE-129 sodium	Bacterial Antibiotic	Infection
Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent **tyrosine phosphatase inhibitor against mPTPB*, a virulent phosphatase* from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-123856

MY10	Phosphatase NF-κB c-Met/HGFR Anaplastic lymphoma kinase (ALK)	Cardiovascular Disease Neurological Disease
MY10 is a potent and orally active *receptor protein tyrosine* phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65** expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases .

HY-100625

BVT948 2 Publications Verification	Phosphatase Cytochrome P450 Histone Methyltransferase	Cancer
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A).

HY-131132

JAB-3068 SHP2-IN-6	SHP2 Phosphatase	Cancer
JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC₅₀ of 25.8 nM .

HY-115496

7-BIA 1 Publications Verification	Phosphatase	Neurological Disease
7-BIA is a *receptor-type protein tyrosine* phosphatase D (PTPRD) inhibitor with an IC₅₀** of ~1-3 μM .

HY-100462

PTP1B-IN-2 4 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

HY-N0374

Licochalcone C 4 Publications Verification	Glycosidase	Metabolic Disease
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

HY-12219

MSI-1436 Trodusquemine; Aminosterol-1436	Phosphatase	Endocrinology
MSI-1436 is a selective, non-competitive inhibitor of the enzyme *protein-tyrosine* phosphatase 1B (PTP1B), with an IC₅₀** of appr 1 μM, 200-fold preference over TCPTP (IC₅₀, 224 μM).

HY-101964

SPI-112 1 Publications Verification	SHP2 Phosphatase	Cancer
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively .

HY-18667

LTV-1	Phosphatase	Inflammation/Immunology
LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC₅₀ of 508 nM. LTV-1 has the potential for autoimmunity treatment .

HY-15756

PTP1B-IN-4 1 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC₅₀ of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .

HY-12312

TCS 401 2 Publications Verification	Phosphatase	Metabolic Disease
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

HY-111489B

LMPTP inhibitor 1 dihydrochloride	Phosphatase	Metabolic Disease
LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC₅₀ of 0.8 μM LMPTP-A.

HY-133146

DJ001	Phosphatase Apoptosis	Inflammation/Immunology
DJ001 is a highly specific, selective and non-competitive *protein tyrosine* phosphatase-σ (PTPσ) inhibitor with an IC₅₀** of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration .

HY-18756A

NSC-87877 disodium 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Cancer
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits *dual-specificity phosphatase* 26 (DUSP26)** .

HY-131132A

JAB-3068 hydrochloride SHP2-IN-6 hydrochloride	SHP2 Phosphatase	Cancer
JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC₅₀ of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7 .

HY-N4185

Licoflavone A 3 Publications Verification	Phosphatase	Neurological Disease
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-123846

MLS-0437605 1 Publications Verification	Phosphatase	Cardiovascular Disease
MLS-0437605 is a selective *dual-specificity phosphatase* 3 (DUSP3) inhibitor with an IC₅₀** of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .

HY-N2451

Aloe-emodin-8-O-β-D-glucopyranoside 1 Publications Verification	Phosphatase	Metabolic Disease Endocrinology
Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of *human protein tyrosine* phosphatase 1B (hPTP1B) with an IC₅₀** of 26.6 μM .

HY-136595

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .

HY-19779

JTT 551	Phosphatase	Metabolic Disease
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

HY-P0320

EGF Receptor Substrate 2 (Phospho-Tyr5)	Phosphatase	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-171615

(4-Phenylphenoxy)phosphonic acid	Phosphatase	Infection
(4-Phenylphenoxy) phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (K_M: 86 μM). (4-Phenylphenoxy) phosphonic acid can be used in tuberculosis research .

HY-N6650

Isotanshinone IIA	Phosphatase	Metabolic Disease
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-151591

SPAA-52	Phosphatase	Metabolic Disease
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC₅₀=4 nM, K_i=1.2 nM). SPAA-52 can be used in diabete research .

HY-B0537AS

Pentamidine-d4 dihydrochloride MP-601205-d4 dihydrochloride	Isotope-Labeled Compounds Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-N4143

Cyanidin 3-arabinoside	Phosphatase	Metabolic Disease
Cyanidin 3-arabinoside is a selective and reversible *protein tyrosine* phosphatase 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-N12177

Cryptosporioptide A	Phosphatase SHP1	Metabolic Disease
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-120159

GS-493	SHP2 SHP1 Phosphatase	Cancer
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC₅₀ of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity .

HY-N2111

Momordicoside A	Phosphatase	Metabolic Disease
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on *protein tyrosine* phosphatase (PTP1B)** .

HY-N1230

Sophoraisoflavone A Allolicoisoflavone B	Phosphatase	Inflammation/Immunology
Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent *protein tyrosine* phosphatase 1B (PTP1B) inhibitor with an IC₅₀** value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .

HY-B1474

Alexidine	Fungal	Infection Cancer
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .

HY-135477

RWJ-60475	Phosphatase Bacterial	Infection
RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC₅₀ of 3.3 μM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase, interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Phosphatase Apoptosis Autophagy	Inflammation/Immunology Cancer
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent *protein tyrosine* phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy** through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-125260

SHP844	SHP2	Cancer
SHP844 is a SHP2 inhibitor with the IC₅₀ of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival .

HY-B0537A

Pentamidine dihydrochloride MP-601205 dihydrochloride	Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite *Leishmania infantum* with an IC₅₀ of 2.5 μM. Pentamidine dihydrochloride is a potent and selective *protein tyrosine* phosphatases (PTPases)** and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-N16588

cis-Emodin-physcion bianthrone	Phosphatase	Metabolic Disease
cis-Emodin-physcion bianthrone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 7.29 μM. cis-Emodin-physcion bianthrone can be used for research on type 2 diabetes .

HY-W174279

Tyrphostin 8	EGFR Ras Phosphatase	Metabolic Disease
Tyrphostin 8 is a tyrosine kinase, with an IC₅₀ of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein *serine/threonine phosphatase* calcineurin (IC₅₀**=21 μM) .

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1549

Prunin 4 Publications Verification Naringenin 7-0-glucoside	Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Enterovirus Phosphatase
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 5.5 μM .

HY-N0374

Licochalcone C 4 Publications Verification	Chalcones Flavonoids Classification of Application Fields Leguminosae Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Glycosidase
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

HY-N6082

Rhein 8-O-β-D-Glucopyranoside 1 Publications Verification	Quinones Structural Classification Monophenols Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Metabolic Disease Plants Disease Research Fields Source Classification	Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial
Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

HY-N4185

Licoflavone A 3 Publications Verification	Flavonoids Neurological Disease Classification of Application Fields Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Phosphatase
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-N2451

Aloe-emodin-8-O-β-D-glucopyranoside 1 Publications Verification	Quinones Monophenols Liliaceae Classification of Application Fields Anthraquinones Phenols Aloe vera (L.) Burm. f. Metabolic Disease Plants Disease Research Fields Source Classification	Phosphatase
Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of *human protein tyrosine* phosphatase 1B (hPTP1B) with an IC₅₀** of 26.6 μM .

HY-N12614

Diorcinol	Microorganisms Marine natural products Phenols Polyphenols Marine microorganism Source Classification	SHP1 Phosphatase
Diorcinol is a potent SHP1 inhibitor with an IC₅₀ value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research .

HY-N6650

Isotanshinone IIA	Quinones Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Metabolic Disease Plants Naphthalene Quinones Disease Research Fields Source Classification	Phosphatase
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-N9551

Eriodictyol chalcone	Structural Classification Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Disease Research Fields Source Classification	Cytochrome P450 Parasite COX Lipoxygenase
Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC₅₀=0.043 μM), aromatase/CYP19A1 (IC₅₀=2.8 μM), PTPase 1B (IC₅₀=1.26 μM), and COX (IC₅₀=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases .

HY-N4143

Cyanidin 3-arabinoside	other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Phosphatase
Cyanidin 3-arabinoside is a selective and reversible *protein tyrosine* phosphatase 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-N12177

Cryptosporioptide A	Flavonoids Microorganisms Other Flavonoids Source Classification	Phosphatase SHP1
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-N2111

Momordicoside A	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Plants Disease Research Fields Momordica charantia Linn. Source Classification	Phosphatase
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on *protein tyrosine* phosphatase (PTP1B)** .

HY-N1230

Sophoraisoflavone A Allolicoisoflavone B	Flavonoids Leguminosae Glycyrrhiza inflata Batal. Plants Isoflavones Source Classification	Phosphatase
Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent *protein tyrosine* phosphatase 1B (PTP1B) inhibitor with an IC₅₀** value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .

HY-N3734

Deoxyneocryptotanshinone	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Beta-secretase Phosphatase
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of *protein tyrosine* phosphatase 1B (PTP1B) with an IC₅₀** value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent *protein tyrosine* phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy** through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-N16588

cis-Emodin-physcion bianthrone	Structural Classification Leguminosae Senna Mill. Phenols Polyphenols Plants Senna tora (L.) Roxb. Source Classification	Phosphatase
cis-Emodin-physcion bianthrone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 7.29 μM. cis-Emodin-physcion bianthrone can be used for research on type 2 diabetes .

HY-N8200

Cassiaside B2	Monophenols Classification of Application Fields Phenols Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Inflammation/Immunology Disease Research Fields Source Classification	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

HY-N12613

Sydowimide A	Natural Products Microorganisms Marine natural products Marine microorganism Source Classification	SHP1 Phosphatase
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Phenols Metabolic Disease Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Disease Research Fields Source Classification	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N1743

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)	Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Moraceae Broussonetia kazinoki Sieb. et Zucc. Disease Research Fields Source Classification	Phosphatase
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes .

HY-N3267

Methyl pseudolarate B	Pinaceae Terpenoids Diterpenoids Pseudolarix amabilis (J. Nelson) Rehder Plants Source Classification	Phosphatase
Methyl pseudolarate B, a natural diterpenoid, is a *protein tyrosine* phosphatase 1B (PTP1B)** (Phosphatase) inhibitor with an IC₅₀ value of 10.9 μM .

HY-N10648

PTP1B-IN-20	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-20 is a selective inhibitor of *protein tyrosine* phosphatase 1B (PTP1B; IC₅₀*=1.05 μM) over the highly homologous T-cell protein tyrosine* phosphatase (TCPTP; IC₅₀=78.0 μM), which is a key target for type 2 diabetes inhibition .

HY-N15015

Dephostatin	Natural Products Microorganisms Source Classification	Phosphatase
Dephostatin is a competitive protein tyrosine phosphatase (PTP) inhibitor that can be isolated from Streptomyces spp., with activity in the micromolar range .

HY-N12736

Dehydrodanshenol A	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants Source Classification	Phosphatase
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .

HY-N15308

Kanjone	Natural Products Millettia peguensis Ali Leguminosae Plants Source Classification	Phosphatase
Kanjone is a compound found in Millettia peguensis and can be used for the synthesis of protein tyrosine phosphatase 1B (PTP1B) inhibitors. Kanjone holds promise for research in the fields of diabetes and neurological disorders .

HY-N10064

Ficusonolide	Triterpenes other families Classification of Application Fields Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Others
Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

HY-N16508

3-Hydroxyphloridzin 3-Hydroxyphlorizin	Structural Classification Phenols Polyphenols Thonningia sanguinea Vahl Plants Balanophoraceae Source Classification	Phosphatase
3-Hydroxyphloridzin (3-Hydroxyphlorizin) is a protein tyrosine phosphatase 1B (PTP1B) inhibitor. 3-Hydroxyphloridzin modulates insulin receptor phosphorylation levels. 3-Hydroxyphloridzin is promising for research of type 2 diabetes .

HY-N12776

Illudalic acid	Microorganisms Terpenoids Sesquiterpenes Source Classification	Phosphatase
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue .

HY-N7599

Chrysophanol triglucoside	Quinones Monophenols Classification of Application Fields Anthraquinones Phenols Metabolic Disease Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Disease Research Fields Source Classification	Phosphatase Glycosidase
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits *protein tyrosine* phosphatases 1B (PTP1B) and α-glucosidase with IC₅₀**s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

HY-163899

(+)-Crinatusin A1	Other Monoterpenes Terpenoids Myrtaceae Plants Syzygium nervosum Candolle Source Classification	Phosphatase
(+)-Crinatusin A1 (Compound (+)- 4) is a chalcone-monoterpene hybrid, which can be isolated from Cleistocalyx operculatus. (+)-Crinatusin A1 is an inhibitor for *protein tyrosine* phosphatase 1B (PTP1B) with IC₅₀** of 0.9 μM. (+)-Crinatusin A1 exhibits potential as an antidiabetic agent .

HY-N1783

(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Phosphatase
(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor, with an IC₅₀ of 0.4 μM. (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid exhibits potent PTP1B inhibitory activity without cytotoxicity .

HY-N12761

Penpaxilloids A	Terpenoids Marine natural products Diterpenoids Marine microorganism Source Classification	Phosphatase Glycosidase
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .

HY-N2451R

Aloe-emodin-8-O-β-D-glucopyranoside (Standard)	Quinones Structural Classification Monophenols Liliaceae Anthraquinones Phenols Aloe vera (L.) Burm. f. Plants Source Classification	Reference Standards Phosphatase
Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC₅₀ of 26.6 μM .

HY-N17455

Albafuran A	Structural Classification Morus nigra Linn. Phenols Polyphenols Plants Moraceae Source Classification	Phosphatase
Albafuran A (Compound 1/4) is a *protein tyrosine* phosphatase 1B (PTP1B**) inhibitor and can be used in research related to type 2 diabetes and obesity .

HY-N16588A

trans-Emodin-physcion bianthrone	Structural Classification Xanthones Polygonaceae Reynoutria japonica Houtt. Phenols Plants Source Classification	Phosphatase
trans-Emodin-physcion bianthrone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 2.77 μM. trans-Emodin-physcion bianthrone is applicable to research related to insulin resistance .

HY-N19818

Glycybridin C	Structural Classification Glycyrrhiza glabra Linn. Leguminosae Phenols Polyphenols Plants Source Classification	Phosphatase NF-κB Pregnane X Receptor (PXR)
Glycybridin C is a *Protein tyrosine* phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB** transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma .

HY-N17424

Mulberrofuran D	Structural Classification Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	Phosphatase
Mulberrofuran D is a protein tyrosine *phosphatase* 1B (PTP1B) inhibitor, with an IC₅₀ of 11.61 μM and a K_i of 4.79 μM against human PTP1B. Mulberrofuran D can be used in research related to type 2 diabetes .

HY-N17326

Ilekudinol B	Weigela subsessilis (Nakai) L.H.Bailey Structural Classification Caprifoliaceae Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Acyltransferase Phosphatase Interleukin Related
Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC₅₀ of 5.3 μM and a K_i of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC₅₀ of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0537AS

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-B1474S1

Alexidine-d10
Alexidine-d₁₀ is the deuterium labeled Alexidine (HY-B1474). Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .

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Species:	Human (34) Mouse (8)
Tag:	His (30) Tag Free (5) Avi (2) Myc (1) GST (10) Fc (4)
Source:	HEK293 (13) Sf9 insect cells (15) E. coli (14)


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Host:	Mouse (18) Rabbit (25)
Reactivity:	Human (36) Rat (7) Mouse (14) human (4)
Application:	IHC-P (23) ICC/IF (20) IF-Tissue (5) IP (16) IHC-F (7) WB (36) FC (15) ELISA (10)
Isotype:	IgG (23) IgG1 (8) IgG/Kappa (2) IgG2a (3) IgG2b (5)
Conjugation:	Non-conjugated (41) PE, Cy7 (1) Alexa Fluor® 647 (1) Biotin (1)
Clonality:	Polyclonal (1) Monoclonal (28) Recombinant (15)
Modification:	Phosphorylated (3) Unmodified (31)


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