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Cat. No.: HY-182483

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Ethyl-3,4-dephostatin

Ethyl-3,4-dephostatin is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 0.58 μg/mL. Ethyl-3,4-dephostatin can be used in studies of PTP1B-related enzyme inhibition mechanisms.

For research use only. We do not sell to patients.

CAS No.: 237756-11-5
Formula: C₈H₁₀N₂O₃
Molecular Weight:182.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ethyl-3,4-dephostatin Chemical Structure

CAS No.: 237756-11-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Ethyl-3,4-dephostatin (7a) (15 min pre-incubation; 10 min enzyme reaction) potently inhibits purified PTP1B with an IC₅₀ of 0.58 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 237756-11-5
Molecular Weight 182.18
Formula C₈H₁₀N₂O₃
SMILES

O=NN(CC)C1=CC=C(C(O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Watanabe T, et al. Structure–Activity Relationship and Rational Design of 3,4-Dephostatin Derivatives as Protein Tyrosine Phosphatase Inhibitors. Tetrahedron. 2000 Jan 28;56(5):741-752.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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