Cat. No.: HY-123856

MY10

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MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 2204270-73-3
Formula: C₁₅H₁₀F₆OS₂
Molecular Weight:384.36

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MY10 Chemical Structure

CAS No.: 2204270-73-3

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(In Japan)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

receptor protein tyrosine phosphatase (RPTPβ/ζ)^[1]

All NF-κB Isoforms :

In Vitro

MY10 (0.1-10 μM, 24 h) decreases the viability of both SH-SY5Y neuroblastoma cells and BV2 microglial cells^[2].
MY10 (10 μM) increases proliferation, migration, and tube formation of Ptprz1^+/+ pulmonary microvascular endothelial cells (LMVECs)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MY10 (100 mg/kg, p.o., 1 h before the voluntary alcohol consumption) reduces the alcohol consumption in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Wistar rats (male, 375-440 g) in alcohol operant self- administration paradigm and Drinking In the Dark - Multiple Scheduled Access (DID-MSA) paradigm^[5]
Dosage:

20, 60, 100 mg/kg (in 10% dehydrated ethanol, 20% polysorbate 80, and 70% PEG 300 vehicle)
Administration:

Administered by oral gavage, once 1 hour before the voluntary alcohol consumption, for 3 days.
Result:

Caused a significant 26.1% reduction in alcohol consumption at 100 mg/kg (in the alcohol operant self-administration paradigm).
Caused a 28.1% decrease in cumulative alcohol intake (in the DID-MSA paradigm).
Decreased the alcohol preference.
Had no effect on saccharin intake.
Prevented the alcohol-induced down-regulation of Prprzl and Alk gene expression.

Chemical Information

CAS No. 2204270-73-3
Appearance Solid
Molecular Weight 384.36
Formula C₁₅H₁₀F₆OS₂
Color White to off-white
SMILES

FC(SC1=CC=C(C=C1)COC2=CC=C(SC(F)(F)F)C=C2)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (130.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6017 mL

13.0086 mL

26.0173 mL

5 mM

0.5203 mL

2.6017 mL

5.2035 mL

10 mM

0.2602 mL

1.3009 mL

2.6017 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. [Content Brief]

[2]. Del Campo M, et al. Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease. Int J Mol Sci. 2021 Jun 22;22(13):6646. [Content Brief]

[3]. Fernández-Calle R, et al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. [Content Brief]

[4]. Kastana P, et al. Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth. Int J Cancer. 2023 Sep 1;153(5):1051-1066. [Content Brief]

[5]. Calleja-Conde J, et al. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcohol Clin Exp Res. 2020 May;44(5):1037-1045. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6017 mL	13.0086 mL	26.0173 mL	65.0432 mL
	5 mM	0.5203 mL	2.6017 mL	5.2035 mL	13.0086 mL
	10 mM	0.2602 mL	1.3009 mL	2.6017 mL	6.5043 mL
	15 mM	0.1734 mL	0.8672 mL	1.7345 mL	4.3362 mL
	20 mM	0.1301 mL	0.6504 mL	1.3009 mL	3.2522 mL
	25 mM	0.1041 mL	0.5203 mL	1.0407 mL	2.6017 mL
	30 mM	0.0867 mL	0.4336 mL	0.8672 mL	2.1681 mL
	40 mM	0.0650 mL	0.3252 mL	0.6504 mL	1.6261 mL
	50 mM	0.0520 mL	0.2602 mL	0.5203 mL	1.3009 mL
	60 mM	0.0434 mL	0.2168 mL	0.4336 mL	1.0841 mL
	80 mM	0.0325 mL	0.1626 mL	0.3252 mL	0.8130 mL
	100 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6504 mL

Keywords

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MY10

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Phosphatase Inhibitor Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Antidepressant Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All NF-κB Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MY10 Related Classifications

Cat. No.: HY-123856