2204270-73-3
Chemical Structure
MY10
- CAS No.: 2204270-73-3
- Formula:C15H10F6OS2
- Molecular Weight:384.36
IUPAC Name: (trifluoromethyl)(4-((4-((trifluoromethyl)thio)benzyl)oxy)phenyl)sulfane
InChIKey: OJUUGOMDHJFXJH-UHFFFAOYSA-N
SMILES: FC(SC1=CC=C(C=C1)COC2=CC=C(SC(F)(F)F)C=C2)(F)F
Biological Activity: MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases[1][2][3][4][5].
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MY10 | 99.86% | MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases. | ||||||||||||||||||||
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References
- [1]. Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. [Content Brief]
- [2]. Del Campo M, et al. Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease. Int J Mol Sci. 2021 Jun 22;22(13):6646. [Content Brief]
- [3]. Fernández-Calle R, et al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. [Content Brief]
- [4]. Kastana P, et al. Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth. Int J Cancer. 2023 Sep 1;153(5):1051-1066. [Content Brief]
- [5]. Calleja-Conde J, et al. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcohol Clin Exp Res. 2020 May;44(5):1037-1045. [Content Brief]
