1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. MY33-3

MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction.

For research use only. We do not sell to patients.

MY33-3 Chemical Structure

MY33-3 Chemical Structure

CAS No. : 2204280-41-9

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5 mg USD 320 In-stock
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25 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].

IC50 & Target

IC50: 0.1 μM (RPTPβ/ζ), 0.7 μM (PTP-1B)[1]

In Vitro

MY33-3 (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells[1].
MY33-3 (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 1 μM
Incubation Time: Pretreated for 5 min and co-treated for 15 min
Result: Decreased the Ethanol-induced activation of TrkA and ALK.
None of the treatments significantly changed total TrkA or total ALK protein levels.
In Vivo

MY33-3 (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 reduces preference for the ethanol solution on day 3[1].
MY33-3 (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8-10 weeks of age) are received two-bottle drinking in the dark (DID) procedure using 20% ethanol[1]
Dosage: 60 mg/kg
Administration: P.o. 1 hour before the drinking session in the DID test on days 3 and 4
Result: Reduced ethanol consumption when comparing day 2 with day 3.
Showed a reduced preference for the ethanol solution.
Not affected total fluid consumption.
Molecular Weight

397.40

Formula

C16H13F6NS2

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC(SC1=CC=C(CNCC2=CC=C(SC(F)(F)F)C=C2)C=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (25.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5164 mL 12.5818 mL 25.1636 mL
5 mM 0.5033 mL 2.5164 mL 5.0327 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5164 mL 12.5818 mL 25.1636 mL 62.9089 mL
5 mM 0.5033 mL 2.5164 mL 5.0327 mL 12.5818 mL
10 mM 0.2516 mL 1.2582 mL 2.5164 mL 6.2909 mL
15 mM 0.1678 mL 0.8388 mL 1.6776 mL 4.1939 mL
20 mM 0.1258 mL 0.6291 mL 1.2582 mL 3.1454 mL
25 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5164 mL
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MY33-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MY33-3
Cat. No.:
HY-123966
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