PTPRB Antibody (YA7040)
(Synonyms: HPTP BETA antibody; HPTPB antibody; Phosphacan receptor type B antibody; Protein tyrosine phosphatase receptor type B antibody; Protein-tyrosine phosphatase beta antibody; PTPB antibody; Ptprb antibody; PTPRB_HUMAN antibody; R PTP BETA antibody; R-PTP-beta antibody)PTPRB Antibody (YA7040) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTPRB.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:1,000 |
Product Details
PTPRB Antibody (YA7040) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTPRB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 224kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 224kDa
Recombinant protein within Human PTPRB aa 1,018-1,161 / 1,997.
Endogenous
Protein G affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Envío
Shipping with blue ice.
Background
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Function
PTPRB plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin
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Subcellular Localization
Membrane
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Expression
Induction: Up-regulated by hypoxia
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Isoforms & Post-Translational Modification
P23467 has four isomers: P23467-1: 224301 Da (predicted); P23467-2: 214209 Da (predicted); P23467-3: 249143 Da (predicted); P23467-4: 214505 Da (predicted).
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Subunit
Monomer
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SwissProt ID
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Synonyms
HPTP BETA antibody; HPTPB antibody; Phosphacan receptor type B antibody; Protein tyrosine phosphatase receptor type B antibody; Protein-tyrosine phosphatase beta antibody; PTPB antibody; Ptprb antibody; PTPRB_HUMAN antibody; R PTP BETA antibody; R-PTP-beta antibody
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