1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. 7-BIA

7-BIA 

Cat. No.: HY-115496
Handling Instructions

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM.

For research use only. We do not sell to patients.

7-BIA Chemical Structure

7-BIA Chemical Structure

CAS No. : 1313403-49-4

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Description

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].

IC50 & Target

IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)[1]

In Vitro

7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1–3 μM and 40 μM, respectively[1].

In Vivo

7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1].

Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions)[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Given i.p.; only once
Result: Reduced cocaine self-administration in highly experienced WT mice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

294.30

Formula

C₁₅H₁₈O₆

CAS No.

1313403-49-4

SMILES

O=CC1=C(C2=CC(OCCCC)=C1OC)CC(O)OC2=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
7-BIA
Cat. No.:
HY-115496
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7-BIA

Cat. No.: HY-115496