1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. 7-BIA

7-BIA 

Cat. No.: HY-115496 Purity: >98.0%
Handling Instructions

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM.

For research use only. We do not sell to patients.

7-BIA Chemical Structure

7-BIA Chemical Structure

CAS No. : 1313403-49-4

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1].

IC50 & Target

IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)[1]

In Vitro

7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1–3 μM and 40 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions)[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Given i.p.; only once
Result: Reduced cocaine self-administration in highly experienced WT mice.
Molecular Weight

294.30

Formula

C₁₅H₁₈O₆

CAS No.

1313403-49-4

SMILES

O=CC1=C(C2=CC(OCCCC)=C1OC)CC(O)OC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (424.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3979 mL 16.9895 mL 33.9789 mL
5 mM 0.6796 mL 3.3979 mL 6.7958 mL
10 mM 0.3398 mL 1.6989 mL 3.3979 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (21.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (21.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (21.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

7-BIAPhosphataseInhibitorinhibitorinhibit

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7-BIA
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HY-115496
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