Mouse Anti-Human CD45 Antibody (AF647)(YA3465)
(Synonyms: PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45)Mouse Anti-Human CD45 Antibody (AF647) (YA3465) is an AF647-conjugated and Mouse origined IgG1 monoclonal antibody , targeting to CD45.
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Host:
Mouse
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Isotype:
IgG
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% Proclin300, 1% BSA.
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Conjugation:
AF647
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5μL per test for million cells or whole blood in 100 μL volume. |
Product Details
Mouse Anti-Human CD45 Antibody (AF647) (YA3465) is an AF647-conjugated and Mouse origined IgG1 monoclonal antibody , targeting to CD45.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 150 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 147 kDa
A synthesized peptide derived from Human CD45.
Protein A affinity purified.
AF647
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% Proclin300, 1% BSA.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD45 (PTPRC/LCA) is a receptor-type protein tyrosine phosphatase common to all white blood cells and is the most classic pan-marker of immune cells. CD45 can be used to label hematopoietic cells, regulate TCR, BCR, and NK cell activation signals, and control immune cell development, differentiation, and function.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane raft; Synapse
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Expression
Tissue_specificity:Isomer 1: Detected in thymocytes. Isomer 2: Detected in thymocytes. Isomer 3: Detected in thymocytes. Isomer 4: Not detected in thymocytes. Isomer 5: Detected in thymocytes. Isomer 6: Not detected in thymocytes. Isomer 7: Detected in thymocytes. Isomer 8: Not detected in thymocytes. -
Isoforms & Post-Translational Modification
CD45 has 8 isomers: P08575-3: 147486 Da (predicted); P08575-4: 131130 Da (predicted); P08575-5: 142623 Da (predicted); P08575-6: 142898 Da (predicted); P08575-7: 140582 Da (predicted); P08575-8: 138034 Da (predicted); P08575-9: 135719 Da (predicted); P08575-10: 135993 Da (predicted).
Heavily N- and O-glycosylated -
Subunit
Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes
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SwissProt ID
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Synonyms
PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45
Documentation
References
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