1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. LYP-IN-1

LYP-IN-1 

Cat. No.: HY-108944
Handling Instructions

LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders.

For research use only. We do not sell to patients.

LYP-IN-1 Chemical Structure

LYP-IN-1 Chemical Structure

CAS No. : 1404436-51-6

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Description

LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders[1].

IC50 & Target

IC50: 0.259 μM (LYP)
Ki: 110 nM (LYP)[1]

In Vitro

LYP-IN-1 has inhibitory activity toward a panel of mammalian PTPs including SHP1, SHP2, PTP-Meg2, FAP1 and PTP-PEST, with IC50 values of 5 μM, 2.5 μM, 0.59 μM, 0.39 μM, and 0.8 μM, respectively[1].
LYP-IN-1 (15 µM) increases both basal and TCR-stimulated phosphorylation of ZAP-70 on Tyr319 in JTAg cells[1].
LYP-IN-1 (15 µM) treatment of mouse thymocytes effectively causes an increase in the activation of double-positive (DP) thymocytes, it increased surface expression of CD69 (a marker of T cell activation) and Nur77[1].

Molecular Weight

501.91

Formula

C₂₈H₂₀ClNO₆

CAS No.

1404436-51-6

SMILES

O=C(C1=C(O)C=C(OC(C2=CC=C(OCC(NC3CC3)=O)C=C2)=C4C#CC5=CC=CC(Cl)=C5)C4=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LYP-IN-1PhosphataseLymphoid-specifictyrosinephosphatase?JTAg?LYPSHP1SHP2PTP-Meg2FAP1CD69BMMCanti-autoimmuneInhibitorinhibitorinhibit

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LYP-IN-1
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HY-108944
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