1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor Monoamine Oxidase
  3. TC-2153

TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling.

For research use only. We do not sell to patients.

TC-2153 Chemical Structure

TC-2153 Chemical Structure

CAS No. : 1381769-23-8

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 255 In-stock
25 mg USD 575 In-stock
50 mg USD 950 In-stock
100 mg USD 1580 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].

IC50 & Target

5-HT1A Receptor

 

5-HT2A Receptor

 

MAO-A

 

In Vitro

TC-2153 (10 μM; 3 h) decreases the percentage of DOI (HY-103124)-induced c-fos positive neurons in cortical and hippocampal neurons cultured in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chronic TC-2153 treatment: TC-2153 (20 mg/kg; i.p.; once daily for 7 d) shows antidepressant-like effect without altering locomotor, exploratory activity and anxiety[1].
Acute TC-2153 treatment: TC-2153 (10 mg/kg and 20 mg/kg; p.o.; single dose) inhibits the functional activity of 5-HT2A receptors in vivo in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF-state adult mouse males[1]
Dosage: 10 mg/kg and 20 mg/kg; with or without 1 mg/kg DOI i.p. at 3 h after final treatment
Administration: Oral gavage or intraperitoneal injection; single dose or once daily for 7 d
Result: Showed antidepressant-like effect in the forced swim test without any adverse side effects on locomotor activity, anxiety, exploration, motor skill and obsessive-compulsive-like behavior.
Both acute and chronic methods inhibited the functional activity of 5-HT2A receptors.
Molecular Weight

355.89

Formula

C7H5ClF3NS5

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=C2SSSSSC2=CC(C(F)(F)F)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (280.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8099 mL 14.0493 mL 28.0986 mL
5 mM 0.5620 mL 2.8099 mL 5.6197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8099 mL 14.0493 mL 28.0986 mL 70.2464 mL
5 mM 0.5620 mL 2.8099 mL 5.6197 mL 14.0493 mL
10 mM 0.2810 mL 1.4049 mL 2.8099 mL 7.0246 mL
15 mM 0.1873 mL 0.9366 mL 1.8732 mL 4.6831 mL
20 mM 0.1405 mL 0.7025 mL 1.4049 mL 3.5123 mL
25 mM 0.1124 mL 0.5620 mL 1.1239 mL 2.8099 mL
30 mM 0.0937 mL 0.4683 mL 0.9366 mL 2.3415 mL
40 mM 0.0702 mL 0.3512 mL 0.7025 mL 1.7562 mL
50 mM 0.0562 mL 0.2810 mL 0.5620 mL 1.4049 mL
60 mM 0.0468 mL 0.2342 mL 0.4683 mL 1.1708 mL
80 mM 0.0351 mL 0.1756 mL 0.3512 mL 0.8781 mL
100 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7025 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TC-2153
Cat. No.:
HY-124591
Quantity:
MCE Japan Authorized Agent: