Illudalic acid
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC50 value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue.
For research use only. We do not sell to patients.
- CAS No.: 18508-77-5
- Formula: C15H16O5
- Molecular Weight:276.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.30 µM (LAR phosphatase)[1]
Chemical Information
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CAS No. 18508-77-5
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Molecular Weight 276.28
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Formula C15H16O5
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SMILES
CC1(CC2=C(C(C=O)=C3CC(OC(C3=C2C1)=O)O)O)C
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Structure Classification
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Initial Source
Clitocybe illudens
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hansen DT, et al. The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Bioorg Med Chem Lett. 2024 May 15;104:129740. [Content Brief]
[2]. Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem. 2008 Aug 1;16(15):7399-409. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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