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Art. -Nr.: HY-N12776

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Illudalic acid

Illudalic acid is a sesquiterpenoid natural product discovered in Omphalotus illudens. Illudalic acid inhibits LAR with an IC₅₀ of 2.1 µM, and also inhibits CD45, PTPμ, and SHP2. Illudalic acid derivatives inhibit PTPRD and reduce drug-induced reward behavior in animal models. Illudalic acid can be used in research on LAR-related diseases.

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CAS. Nr.: 18508-77-5
Formel: C₁₅H₁₆O₅
Molecular Weight:276.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Illudalic acid Chemical Structure

CAS. Nr.: 18508-77-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 1.30 µM (LAR phosphatase)^[1]

In Vitro

Illudalic acid (IA-30) inhibits LAR with an IC₅₀ of 2.1 µM, and also inhibits CD45 (10 µM), PTPμ (16 µM), and SHP2 (29 µM), whereas its IC₅₀ values against TCPTP, HePTP, PTPε, VHR, and LMWPTP are all >100 µM^[3].
Illudalic acid is a pseudo-irreversible LAR inhibitor, K_I = 130 µM, k_inact = 1.3 min^-1^[3].
Illudalic acid (20 μM; 10 min) irreversibly inhibits recombinant LAR^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Illudalic acid derivative 7-BIA inhibits PTPRD and reduces drug-induced reward effects in mice, but this pharmacological effect is absent in PTPRD heterozygous knockout mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Sucrose Preference Test (SPT)

Chemical Information

CAS. Nr. 18508-77-5
Molecular Weight 276.28
Formel C₁₅H₁₆O₅
SMILES

CC1(CC2=C(C(C=O)=C3CC(OC(C3=C2C1)=O)O)O)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Microorganism
Clitocybe illudens
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Uhl GR, et al. Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D. Frontiers in psychiatry. 2023;14:1031283.

[2]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov 06;115(45):11597-11602. [Content Brief]

[3]. McCullough BS, et al. Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. Journal of natural products. 2019 Dec 27;82(12):3386-3393.

[4]. Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorganic & medicinal chemistry. 2008 Aug 01;16(15):7399-409. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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