18508-77-5
18508-77-5
Chemical Structure
Illudalic acid
- CAS No.: 18508-77-5
- Formula:C15H16O5
- Molecular Weight:276.28
InChIKey: BDEDPKFUFGCVCJ-UHFFFAOYSA-N
SMILES: CC1(CC2=C(C(C=O)=C3CC(OC(C3=C2C1)=O)O)O)C
Biological Activity: Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC50 value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue[1][2].
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Illudalic acid | Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC50 value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue. | |||||||||||||||||||||
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References
- [1]. Hansen DT, et al. The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Bioorg Med Chem Lett. 2024 May 15;104:129740. [Content Brief]
- [2]. Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem. 2008 Aug 1;16(15):7399-409. [Content Brief]
Keywords
