2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. LTV-1

LTV-1 

Cat. No.: HY-18667 Purity: ≥98.0%
COA Handling Instructions

LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment.

For research use only. We do not sell to patients.

LTV-1 Chemical Structure

LTV-1 Chemical Structure

CAS No. : 347379-29-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 220 In-stock
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 320 In-stock
50 mg USD 1100 In-stock
100 mg USD 1680 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

LTV-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment[1].

IC50 & Target

IC50: 508 nM (LYP, in T cells)[1]
In Vitro

LTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LTV-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa cells, Jurkat TAg T cells, and PBMC
Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM
Incubation Time: 48 hours
Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM).
Molecular Weight

472.51

Appearance

Solid

Formula

C26H20N2O5S
CAS No.
SMILES

O=C(O)C1=CC=CC(COC2=CC=C(/C=C(C(N3C4=CC=CC=C4C)=O)\C(NC3=S)=O)C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 22.73 mg/mL (48.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1164 mL 10.5818 mL 21.1636 mL
5 mM 0.4233 mL 2.1164 mL 4.2327 mL
10 mM 0.2116 mL 1.0582 mL 2.1164 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.08 mg/mL (4.40 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (199 KB)

Handling Instructions (2659 KB)
References
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LTV-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LTV-1347379-29-7LTV1LTV 1PhosphataselymphoidtyrosinephosphataseLYPautoimmunityInhibitorinhibitorinhibit

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