1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. LTV-1

LTV-1 

Cat. No.: HY-18667 Purity: ≥98.0%
Handling Instructions

LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment.

For research use only. We do not sell to patients.

LTV-1 Chemical Structure

LTV-1 Chemical Structure

CAS No. : 347379-29-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment[1].

IC50 & Target

IC50: 508 nM (LYP, in T cells)[1]

In Vitro

LTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HeLa cells, Jurkat TAg T cells, and PBMC
Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM
Incubation Time: 48 hours
Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM).
Molecular Weight

472.51

Formula

C₂₆H₂₀N₂O₅S

CAS No.
SMILES

O=C(O)C1=CC=CC(COC2=CC=C(/C=C(C(N3C4=CC=CC=C4C)=O)\C(NC3=S)=O)C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 22.73 mg/mL (48.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1164 mL 10.5818 mL 21.1636 mL
5 mM 0.4233 mL 2.1164 mL 4.2327 mL
10 mM 0.2116 mL 1.0582 mL 2.1164 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.40 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

LTV-1LTV1LTV 1PhosphataselymphoidtyrosinephosphataseLYPautoimmunityInhibitorinhibitorinhibit

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LTV-1
Cat. No.:
HY-18667
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