Eriodictyol chalcone

Cat. No.: HY-N9551 Purity: 97.25%: Data Sheet
COA

SDS
Handling Instructions
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Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC₅₀=0.043 μM), aromatase/CYP19A1 (IC₅₀=2.8 μM), PTPase 1B (IC₅₀=1.26 μM), and COX (IC₅₀=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases.

For research use only. We do not sell to patients.

Eriodictyol chalcone Chemical Structure

CAS No. : 14917-41-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

View All Parasite Isoform Specific Products:

View All Isoforms

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

View All COX Isoform Specific Products:

View All Isoforms

COX COX-1 COX-2 COX-3

View All Lipoxygenase Isoform Specific Products:

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5-LOX 12-LOX 15-LOX

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Aromatase

Plasmodium falciparum sporozoites

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	4.4 μM Compound: 1	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
Neutrophil	IC₅₀	5 μM Compound: 1	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
RBL-1	IC₅₀	0.14 μM Compound: 12	Inhibition of 5-lipoxygenase in rat RBL1 cells Inhibition of 5-lipoxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7
RBL-1	IC₅₀	0.14 μM Compound: 12	Inhibition of cyclooxygenase in rat RBL1 cells Inhibition of cyclooxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7
RBL-1	IC₅₀	0.14 μM Compound: 13	In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined	[PMID: 8254620]

In Vitro

Eriodictyol chalcone (1 mM; 48 h) inhibits growth of the 3D7 Plasmodium falciparum strain by 88% when used at 1 mM for 48 h^[1].
Eriodictyol chalcone (2.5-8.2 μM) inhibits phosphoenolpyruvate carboxylase (PEPC) with IC₅₀ values of 2.5 μM and 8.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Eriodictyol chalcone (10 mg/kg) exerts potent antidepressant activity in mice, as evidenced by a statistically significant reduction in immobility duration in the forced swimming test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.25

Formula

C₁₅H₁₂O₆

CAS No.

14917-41-0

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=C(O)C(O)=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (104.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4692 mL	17.3461 mL	34.6921 mL
5 mM	0.6938 mL	3.4692 mL	6.9384 mL
10 mM	0.3469 mL	1.7346 mL	3.4692 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.25%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (247 KB) HNMR (244 KB) RP-HPLC (258 KB) LCMS (138 KB)

Handling Instructions (2659 KB)

References

[1]. Chacon-Morales P A, et al. Chalcone-flavanone equilibrium in the isomeric mixture: 2', 3, 4, 4', 6'-Pentahydroxychalcone and eriodictyol from Stevia lucida[J]. Avances en Quimica, 2020, 15(3): 89-96.

[2]. Iijima Y, et al. Metabolite profiling of chalcones and flavanones in tomato fruit[J]. Journal of the Japanese Society for Horticultural Science, 2008, 77(1): 94-102.

[3]. Furudate H, et al. A Polyphenol Oxidase Catalyzes Aurone Synthesis in Marchantia polymorpha. Plant Cell Physiol. 2023;64(6):637-645. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4692 mL	17.3461 mL	34.6921 mL	86.7303 mL
	5 mM	0.6938 mL	3.4692 mL	6.9384 mL	17.3461 mL
	10 mM	0.3469 mL	1.7346 mL	3.4692 mL	8.6730 mL
	15 mM	0.2313 mL	1.1564 mL	2.3128 mL	5.7820 mL
	20 mM	0.1735 mL	0.8673 mL	1.7346 mL	4.3365 mL
	25 mM	0.1388 mL	0.6938 mL	1.3877 mL	3.4692 mL
	30 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	40 mM	0.0867 mL	0.4337 mL	0.8673 mL	2.1683 mL
	50 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7346 mL
	60 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	80 mM	0.0434 mL	0.2168 mL	0.4337 mL	1.0841 mL
	100 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL