Eriodictyol chalcone
Based on 1 Customer Validation
Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC50=0.043 μM), aromatase/CYP19A1 (IC50=2.8 μM), PTPase 1B (IC50=1.26 μM), and COX (IC50=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases.
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- Pureté : 97.25%
- CAS No.: 14917-41-0
- Formule: C15H12O6
- Masse moléculaire:288.25
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Aromatase |
Plasmodium falciparum sporozoites |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
4.4 μM
Compound: 1
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| Neutrophil | IC50 |
5 μM
Compound: 1
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| RBL-1 | IC50 |
0.14 μM
Compound: 12
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Inhibition of 5-lipoxygenase in rat RBL1 cells
Inhibition of 5-lipoxygenase in rat RBL1 cells
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10.1007/s00044-013-0745-7 |
| RBL-1 | IC50 |
0.14 μM
Compound: 12
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Inhibition of cyclooxygenase in rat RBL1 cells
Inhibition of cyclooxygenase in rat RBL1 cells
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10.1007/s00044-013-0745-7 |
| RBL-1 | IC50 |
0.14 μM
Compound: 13
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In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
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[PMID: 8254620] |
In Vitro
Eriodictyol chalcone (1 mM; 48 h) inhibits growth of the 3D7 Plasmodium falciparum strain by 88% when used at 1 mM for 48 h[1].
Eriodictyol chalcone (2.5-8.2 μM) inhibits phosphoenolpyruvate carboxylase (PEPC) with IC50 values of 2.5 μM and 8.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14917-41-0
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Appearance Solid
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Masse moléculaire 288.25
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Formule C15H12O6
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Color Yellow to orange
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SMILES
O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=C(O)C(O)=C2
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 30 mg/mL (104.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4692 mL | 17.3461 mL | 34.6921 mL | 86.7303 mL |
| 5 mM | 0.6938 mL | 3.4692 mL | 6.9384 mL | 17.3461 mL | |
| 10 mM | 0.3469 mL | 1.7346 mL | 3.4692 mL | 8.6730 mL | |
| 15 mM | 0.2313 mL | 1.1564 mL | 2.3128 mL | 5.7820 mL | |
| 20 mM | 0.1735 mL | 0.8673 mL | 1.7346 mL | 4.3365 mL | |
| 25 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4692 mL | |
| 30 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8910 mL | |
| 40 mM | 0.0867 mL | 0.4337 mL | 0.8673 mL | 2.1683 mL | |
| 50 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 60 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4455 mL | |
| 80 mM | 0.0434 mL | 0.2168 mL | 0.4337 mL | 1.0841 mL | |
| 100 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL |
Eriodictyol chalcone Related Classifications
HY-N9551 Related Classifications
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