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Cat. No.: HY-N17455

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Albafuran A

Albafuran A (Compound 1/4) is a protein tyrosine phosphatase 1B (PTP1B) inhibitor and can be used in research related to type 2 diabetes and obesity.

For research use only. We do not sell to patients.

CAS No.: 84323-14-8
Formula: C₂₄H₂₆O₄
Molecular Weight:378.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Albafuran A Chemical Structure

CAS No.: 84323-14-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Albafuran A (Compound 1/4) is a protein tyrosine phosphatase 1B (PTP1B) inhibitor and can be used in research related to type 2 diabetes and obesity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	2.62 μM Compound: 9	Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA	[PMID: 19072214]

In Vitro

Albafuran A (Compound 1) (30 min, 37℃) inhibits recombinant human PTP1B enzyme with an IC₅₀ of 9.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 84323-14-8
Molecular Weight 378.46
Formula C₂₄H₂₆O₄
SMILES

C/C(C)=C\CC/C(C)=C/CC1=C(C2=CC3=CC=C(O)C=C3O2)C=C(C=C1O)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hoang DM, et al. Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009;19(23):6759-6761. [Content Brief]

[2]. Wang L, et al. Three new compounds from the barks of Morus nigra. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):897-902. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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