Glycybridin C
Glycybridin C is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 2088505-67-1
- Formula: C25H30O5
- Molecular Weight:410.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Glycybridin C (10 μM; 6 h) activates Nrf2 signaling in HepG2C8 cells[1].
Glycybridin C (10 μM; 24 h) shows weak inhibition of LPS-induced NO production in RAW 264.7 macrophages, with an inhibition rate of 4.1%[1].
Glycybridin C (10 μM; 6 h) inhibits LPS-induced NF-κB transcriptional activity in SW480 cells by 33.4%[1].
Glycybridin C (10 μM; 24 h) inhibits growth of HepG2, SW480, and MCF7 cells by 75.2%, 72.0%, and 82.1% respectively, while having no significant effect on A549 cells[1].
Glycybridin C (10 μM; 30 min) inhibits PTP1B activity by 37.7% in a cell-free assay[1].
Glycybridin C (10 μM; 15 min) does not inhibit tyrosinase activity in a cell-free assay[1].
Glycybridin C binds to the human PXR ligand-binding domain with a high predicted affinity, as indicated by a binding free energy of -67.93 kcal/mol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, SW480, A549, and MCF7 human cancer cell lines
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Concentration:10 μM
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Incubation Time:24 h
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Result:Inhibited cell growth by 75.2% in HepG2 cells.
Inhibited cell growth by 72.0% in SW480 cells.
Inhibited cell growth by 82.1% in MCF7 cells.
Showed no significant inhibition in A549 cells.
Chemical Information
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CAS No. 2088505-67-1
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Molecular Weight 410.50
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Formula C25H30O5
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SMILES
C/C(C)=C\CC(C=C1C[C@@H](O)C(C2=C(C(C/C=C(C)\C)=C(C=C2)O)O)=O)=C(C=C1)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Li K, et al. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. J Nat Prod. 2017 Feb 24;80(2):334-346. [Content Brief]
[2]. Alhusban M, et al. Computational Tools to Expedite the Identification of Potential PXR Modulators in Complex Natural Product Mixtures: A Case Study with Five Closely Related Licorice Species. ACS Omega. 2022;7(30):26824-26843. Published 2022 Jul 21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glycybridin C Related Classifications
HY-N19818 Related Classifications
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