2. Metabolic Enzyme/Protease NF-κB Vitamin D Related/Nuclear Receptor
  3. Phosphatase NF-κB Pregnane X Receptor (PXR)
  4. Glycybridin C

Glycybridin C is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma.

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Glycybridin C

Glycybridin C Chemical Structure

CAS No. : 2088505-67-1

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Glycybridin C Related Antibodies

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Description

Glycybridin C is a Protein tyrosine phosphatase 1B (PTP1B) inhibitor and pregnane X receptor (PXR) ligand. Glycybridin C inhibits insulin and leptin signaling pathway negative regulation, LPS (HY-D1056)-induced NF-κB transcriptional activity. Glycybridin C forms hydrophobic and π-π stacking interactions with Met243, Phe288, Tyr306, and His407 residues of PXR. Glycybridin C can be used for the research of hepatocellular carcinoma, colorectal adenocarcinoma, breast carcinoma[1][2].

In Vitro

Glycybridin C (10 μM; 6 h) activates Nrf2 signaling in HepG2C8 cells[1].
Glycybridin C (10 μM; 24 h) shows weak inhibition of LPS-induced NO production in RAW 264.7 macrophages, with an inhibition rate of 4.1%[1].
Glycybridin C (10 μM; 6 h) inhibits LPS-induced NF-κB transcriptional activity in SW480 cells by 33.4%[1].
Glycybridin C (10 μM; 24 h) inhibits growth of HepG2, SW480, and MCF7 cells by 75.2%, 72.0%, and 82.1% respectively, while having no significant effect on A549 cells[1].
Glycybridin C (10 μM; 30 min) inhibits PTP1B activity by 37.7% in a cell-free assay[1].
Glycybridin C (10 μM; 15 min) does not inhibit tyrosinase activity in a cell-free assay[1].
Glycybridin C binds to the human PXR ligand-binding domain with a high predicted affinity, as indicated by a binding free energy of -67.93 kcal/mol[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycybridin C Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, SW480, A549, and MCF7 human cancer cell lines
Concentration: 10 μM
Incubation Time: 24 h
Result: Inhibited cell growth by 75.2% in HepG2 cells.
Inhibited cell growth by 72.0% in SW480 cells.
Inhibited cell growth by 82.1% in MCF7 cells.
Showed no significant inhibition in A549 cells.
Molecular Weight

410.50

Formula

C25H30O5
CAS No.
SMILES

C/C(C)=C\CC(C=C1C[C@@H](O)C(C2=C(C(C/C=C(C)\C)=C(C=C2)O)O)=O)=C(C=C1)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Glycybridin C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycybridin C2088505-67-1PhosphataseNF-κBPregnane X Receptor (PXR)Nuclear factor-κBNuclear factor-kappaBPregnane X Receptorleptin signaling pathwayProtein tyrosine phosphatase 1BHepG2 cellsRAW 264.7 macrophagesinsulin signaling pathwayNrf2HepG2C8 cellspregnane X receptorSW480 cellsInhibitorinhibitorinhibit

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