PTPN12 Protein, Human (sf9, His-GST)
The PTPN12 protein is a multifunctional enzyme that can dephosphorylate a variety of proteins and regulate cell signaling cascades. According to literature, PTPN12 selectively targets tyrosine kinases such as ERBB2 and PTK2B/PYK2 to control related pathways. PTPN12 Protein, Human (sf9, His-GST) is the recombinant human-derived PTPN12 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The PTPN12 protein is a multifunctional enzyme that can dephosphorylate a variety of proteins and regulate cell signaling cascades. According to literature, PTPN12 selectively targets tyrosine kinases such as ERBB2 and PTK2B/PYK2 to control related pathways. PTPN12 Protein, Human (sf9, His-GST) is the recombinant human-derived PTPN12 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag.
Background
PTPN12 Protein, the subject, functions as a versatile enzyme capable of dephosphorylating a range of proteins, thereby playing a crucial role in the regulation of various cellular signaling cascades, as documented in the literature. Among its substrates, PTPN12 selectively dephosphorylates cellular tyrosine kinases, including ERBB2 and PTK2B/PYK2, exerting regulatory control over signaling pathways involving these kinases. The specificity of PTPN12 is highlighted by its ability to dephosphorylate ERBB2 at specific tyrosine residues, such as 'Tyr-1112,' 'Tyr-1196,' and/or 'Tyr-1248.' The intricate dephosphorylation activity of PTPN12 underscores its significance in modulating key signaling events and fine-tuning cellular responses mediated by tyrosine kinase pathways.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-GST;N-His
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Accession
Q05209 (M1-Q355)
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Molecular Construction
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N-term
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His-GST
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PTPN12 (M1-Q355)
Accession # Q05209 -
C-term
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Protein Length
Partial
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Synonyms
PTPN12; Tyrosine-Protein Phosphatase Non-Receptor Type 12; Protein Tyrosine Phosphatase Non-Receptor Type 12; Protein-Tyrosine Phosphatase G1; PTP-PEST; Protein-Tyrosine-Phosphatase; PTPG1
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AA Sequence
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQ
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Predicted Molecular Mass
69.4 kDa
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Molecular Weight
Approximately 64 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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