PTK2B/PYK2
PTK2B encodes PYK2 (proline-rich tyrosine kinase 2, also called FAK2, CAKβ or RAFTK), the second member of the FAK family. PYK2 shares the FERM-kinase-FAT domain architecture with FAK but lacks an autoinhibitory interaction, rendering it more readily activated by diverse stimuli. Its expression is prominent in the central nervous system and hematopoietic cells. PYK2 is strongly activated by calcium influx and by G-protein-coupled receptors, integrating neuronal excitation, chemokine signaling and osteoclast cytoskeletal remodeling; it contributes to synaptic plasticity, microglial motility and bone resorption. Dysregulated PYK2 participates in anxiety-related behavior, leukemia cell migration and solid tumor metastasis. FAK-family inhibitors generally target both FAK and PYK2, complicating therapeutic attribution of their effects.
-
PTK2B/PYK2 Recombinant Proteins (3)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
