PTPN12 - protein tyrosine phosphatase non-receptor type 12 Gene

Also Known as PTPG1; PTP-PEST

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5782

About PTPN12

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:77,537,295-77,640,069 (from NCBI)

This gene has 16 transcripts (splice variants), 139 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung (RPKM 36.1), placenta (RPKM 29.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

PTPN12 Products (3)

mRNA Protein Name
NM_001131008.2 NP_001124480.1 tyrosine-protein phosphatase non-receptor type 12 isoform 2
NM_001131009.2 NP_001124481.1 tyrosine-protein phosphatase non-receptor type 12 isoform 3
NM_002835.4 NP_002826.3 tyrosine-protein phosphatase non-receptor type 12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
9285683 GOA
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
27134172 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9285683 GOA
enables protein tyrosine phosphatase activity EXP
EXP: Inferred from Experiment
21376233 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IMP
IMP: Inferred from mutant phenotype
27134172 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
27134172 GOA
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
27134172 GOA
involved in regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27134172 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN12 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (58 - 291)

  • 0
  • 200
  • 400
  • 600
  • 780 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 12

  • protein-tyrosine phosphatase G1

PTPN12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPN12 Q05209 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
Intra
PTPN12 Q05209 PSTPIP1 Homo sapiens O43586
Y2H
11971877
Intra
PTPN12 Q05209 PSTPIP1 Homo sapiens O43586
Pull Down
14707117
Intra
PTPN12 Q05209 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
Intra
PTPN12 Q05209 TEK Homo sapiens Q02763
Phosphatase Assay
19167335
Intra
PTPN12 Q05209 EGFR Homo sapiens P00533
Ub Reconstruction
28065597
Intra
PTPN12 Q05209 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
Intra
PTPN12 Q05209 EGFR Homo sapiens P00533
Ub Reconstruction
20029029
Intra
PTPN12 Q05209 ERBB2 Homo sapiens P04626
Phosphatase Assay
19167335
Intra
PTPN12 Q05209 ERBB2 Homo sapiens P04626
BiFC
21376233
Intra
PTPN12 Q05209 PDGFRB Homo sapiens P09619
Affinity Techniques
12614164
Intra
PTPN12 Q05209 BCAR1 Homo sapiens P56945
Pull Down
9285683
Intra
PTPN12 Q05209 BCAR1 Homo sapiens P56945
BioID
27880917
Intra
PTPN12 Q05209 PXN Homo sapiens P49023
Anti Tag CoIP
33961781
Intra
PTPN12 Q05209 PXN Homo sapiens P49023
Phosphatase Assay
19167335
Intra
PTPN12 Q05209 PXN Homo sapiens P49023
BioID
27880917
Intra
PTPN12 Q05209 SHC1 Homo sapiens P29353
BioID
27880917
Intra
PTPN12 Q05209 SHC1 Homo sapiens P29353
Y2H Array
24412244
Intra
PTPN12 Q05209 SHC1 Homo sapiens P29353
Anti Tag CoIP
33961781
Intra
PTPN12 Q05209 SHC1 Homo sapiens P29353
Anti Tag CoIP
27880917
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN12 Proteins

Cat. No. Product Name Accession Purity
HY-P76557 PTPN12 Protein, Human (sf9) Q05209 (N-G&P, M1-Q355) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P76558 PTPN12 Protein, Human (sf9, His-GST) Q05209 (M1-Q355) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

  • Papa Syndrome

  • Fra

  • Familial Recurrent Arthritis

  • Pyogenic Arthritis, Pyoderma Gangrenosum And Acne

  • PAPAS

  • Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome

  • Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne

  • Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne
Leiomyomatosis
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155847 LYP-IN-3 99.80% Unkown
HY-P11604 C16 acid-I-{Lys(C10 diacid)}-KQELRRIGDEF Inhibitor / Unkown
HY-RS11417 PTPN12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19808 Ptpn12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26304 Ptpn12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTPN12 VGNC VGNC:45169
Macaca mulatta PTPN12 VGNC VGNC:76598
Mus musculus PTPN12 MGD MGI:104673
Bos taurus PTPN12 VGNC VGNC:33531
Felis catus PTPN12 VGNC VGNC:69159
Rattus norvegicus PTPN12 RGD RGD:620894
Others PTPN12 NCBI