2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. SBI-0802767

SBI-0802767 is an orally active, uncompetitive and highly selective inhibitor of protein tyrosine phosphatase (LMPTP) with an IC50 of 0.239 μM. SBI-0802767 exhibits >1000-fold selectivity over other protein tyrosine phosphatases and enhances insulin signaling in hepatocytes. SBI-0802767 is used in studies of obesity-related type 2 diabetes and insulin resistance.

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SBI-0802767

SBI-0802767 Chemical Structure

CAS No. : 68220-27-9

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SBI-0802767 Related Antibodies

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Description

SBI-0802767 is an orally active, uncompetitive and highly selective inhibitor of protein tyrosine phosphatase (LMPTP) with an IC50 of 0.239 μM. SBI-0802767 exhibits >1000-fold selectivity over other protein tyrosine phosphatases and enhances insulin signaling in hepatocytes. SBI-0802767 is used in studies of obesity-related type 2 diabetes and insulin resistance[1].

In Vitro

SBI-0802767 (Compound 3) inhibits human LMPTP-A with an IC50 of 0.239 μM and displays >1000-fold selectivity for LMPTP over other PTPs[1].
SBI-0802767 acts as an uncompetitive inhibitor of LMPTP[1].
SBI-0802767 shows moderate plasma protein binding and good microsomal stability in in vitro metabolic studies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SBI-0802767 Related Antibodies
Parmacokinetics
Species Dose Route Cmax AUC T1/2 F CLplasma Vd
Mice[1] 2 mg/kg i.v. / / / / 5.8 mL/min/kg 3.01 L/kg
Mice[1] 10 mg/kg p.o. 5018 ng/mL 18544 ng·h/mL 4.71 h 66 % / /
In Vivo

SBI-0802767 (Compound 3) shows good oral bioavailability (F% = 66) and favorable pharmacokinetic properties in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

294.14

Formula

C12H9Cl2N5
CAS No.
SMILES

ClC1=CC=CC(Cl)=C1CN2C=NC(N)=C3N=CN=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SBI-0802767 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SBI-080276768220-27-9SBI0802767SBI 0802767Phosphatasemiceobesity-induced diabetesdiet-induced obese miceLMPTPprotein tyrosine phosphatasesinsulin resistancelow molecular weight protein tyrosine phosphataseInhibitorinhibitorinhibit

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