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Alpha+reductase+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (20) Acetyl-CoA Carboxylase (1) Akt (5) Aldose Reductase (2) Amino Acid Decarboxylase (1) AMPK (2) Amylases (21) Antibiotic (9) Apoptosis (37) Aryl Hydrocarbon Receptor (1) Aurora Kinase (1) Autophagy (19) Bacterial (12) Bcl-2 Family (1) Bcr-Abl (3) c-Kit (2) Carbonic Anhydrase (2) Carboxypeptidase (1) Caspase (2) CD47 (3) CDK (1) Choline Kinase (1) Cholinesterase (ChE) (1) COX (7) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (3) DGK (2) Dipeptidyl Peptidase (2) DNA-PK (3) Drug Derivative (2) Drug Intermediate (3) Drug Isomer (1) E1/E2/E3 Enzyme (1) EBV (1) EGFR (1) Endogenous Metabolite (11) Enterovirus (1) Environmental Pollutants (7) Epigenetic Reader Domain (1) ERK (4) Estrogen Receptor/ERR (8) FAP (2) FASTK (1) Fatty Acid Synthase (FASN) (3) FGFR (1) Fungal (7) FXR (3) GABA Receptor (3) Glutaminase (1) Glutathione Peroxidase (1) Glutathione S-transferase (2) Glycosidase (159) GSK-3 (12) HCV Protease (1) HIF/HIF Prolyl-Hydroxylase (6) Histone Acetyltransferase (1) HIV (1) HSP (1) IKK (2) Interleukin Related (10) IRE1 (12) Isotope-Labeled Compounds (7) JNK (1) Keap1-Nrf2 (1) Ligands for E3 Ligase (2) Lipase (1) Lipoxygenase (1) MDM-2/p53 (1) Mitophagy (7) MMP (3) Monoamine Oxidase (1) mTOR (2) Natriuretic Peptide Receptor (NPR) (1) NF-κB (7) NO Synthase (8) NOD-like Receptor (NLR) (1) Organoid (7) P-glycoprotein (2) P2X Receptor (2) p38 MAPK (14) PARP (1) PD-1/PD-L1 (1) PDGFR (13) PERK (1) PGC-1α (1) Phosphatase (2) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (14) PKA (5) PKC (1) Potassium Channel (1) PPAR (3) Pregnane X Receptor (PXR) (2) Progesterone Receptor (1) PROTACs (1) Ras (3) Reactive Oxygen Species (ROS) (12) Reference Standards (30) ROCK (1) SARS-CoV (1) Sirtuin (1) Stearoyl-CoA Desaturase (SCD) (1) Survivin (1) Thrombin (2) Thyroid Hormone Receptor (3) TNF Receptor (11) Toll-like Receptor (TLR) (1) Topoisomerase (3) Transmembrane Glycoprotein (1) VEGFR (9) Wnt (8) α-synuclein (20) β-catenin (8)
By Research Areas:	Cancer (118) Cardiovascular Disease (15) Endocrinology (8) Infection (29) Inflammation/Immunology (61) Metabolic Disease (174) Neurological Disease (41)
Oligonucleotides:	Emulsifiers (1)

378

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

105

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0089

Acarbose Maximum Cited Publications 10 Publications Verification BAY g 5421	Glycosidase	Infection Metabolic Disease Cancer
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-B0141A

Alpha-Estradiol Alfatradiol; Epiestradiol; Epiestrol	5 alpha Reductase Endogenous Metabolite Bacterial	Inflammation/Immunology
Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N0472

Geraniin 3 Publications Verification	TNF Receptor	Metabolic Disease Inflammation/Immunology Cancer
Geraniin is a *TNF-α* releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-111387

IDF-11774 5+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Cancer
IDF-11774 is a novel hypoxia-inducible factor α (HIFα)-1 inhibitor with an IC₅₀ of 3.65 μM.

HY-N1200

Stigmasterol glucoside	5 alpha Reductase	Inflammation/Immunology Cancer
Stigmasterol glucoside is a sterol compound and a *5α-reductase* inhibitor with an IC₅₀ value of 27.2 µM. Stigmasterol glucoside has certain anti-inflammatory, antioxidant, and anti-tumor activities .

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and *TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-111507

*PDGFRα kinase inhibitor* 1** 1 Publications Verification	PDGFR	Cancer
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC₅₀s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively .

HY-N7096

Ceftezole sodium CTZ sodium	Bacterial Antibiotic	Infection
Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-113062

20α-Dihydroprogesterone 20-OH-P	Endogenous Metabolite Cytochrome P450	Endocrinology Cancer
20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437). 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC₅₀ about 5 μM .

HY-161074

PNT6555	FAP	Cancer
PNT6555 is a fibroblast activation protein-α (FAP) inhibitor. PNT6555 has antitumor activity. PNT6555 can be used for imaging of FAP-positive tumors .

HY-135530

Chinese gallotannin	Amylases	Metabolic Disease
Chinese gallotannin is a non-specific promiscuous *α-amylase* inhibitor with a K_i of 0.82 μg/mL for human salivary α-amylase. Chinese gallotannin can be used for the research of diabetes .

HY-14305A

BMS-582949 hydrochloride 2 Publications Verification	p38 MAPK Autophagy	Inflammation/Immunology
BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC₅₀ of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease .

HY-157308

*α-Synuclein inhibitor* 10**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 10 (compound a8) inhibits the activity of α-Syn aggregation with low IC₅₀ value (1.08 μM). α-Synuclein inhibitor 10 exhibits good binding affinity to α-Syn residues. α-Synuclein inhibitor 10 can be used in the research of Parkinson's disease (PD) .

HY-N8745

α-Peltatin	Fungal	Others
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-N3706

Dehydro-α-lapachone	Fungal	Infection
Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC₅₀ value 0.41 mg/L .

HY-163145

*α-Synuclein inhibitor* 11**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 11 (compound 1) is a selective α-synuclein (α-syn) oligomer formation inhibitor. α-Synuclein inhibitor 11 does not inhibits tau 4R (isoforms 0N4R, 2N4R) or p-tau (isoform 1N4R). α-Synuclein inhibitor 11 can be used for Parkinson's disease (PD) research .

HY-N17254

Onjisaponin R	Amylases	Metabolic Disease
Onjisaponin R is an *α-amylase* inhibitor. Onjisaponin R can be used in diabetes research .

HY-146752

α-Amylase-IN-1	Amylases	Others
α-Amylase-IN-1 is a potent *α-amylase* inhibitor with an IC_{50 of 4.46 μM .}

HY-129131

Chrysin 6-C-arabinoside 8-C-glucoside	Glycosidase	Metabolic Disease
Chrysin 6-C-arabinoside 8-C-glucoside is a α±-glucosidase* inhibitors* which are widely used in the study for type 2 diabetes .

HY-N1218

Stellasterol	Glycosidase Bcl-2 Family	Others
Stellasterol is a natural product. Stellasterol has high affinity towards Bcl-2 protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor .

HY-N2223

Ganoderol B Ganodermadiol	Glycosidase	Metabolic Disease
Ganoderol B is a potent *α-glucosidase* inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-N10413

Diphlorethohydroxycarmalol	Glycosidase	Metabolic Disease
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active *α-glucosidase* and *α-amylase* inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities .

HY-146128

Anti-hyperglycemic agent-1	Glycosidase	Metabolic Disease
Anti-hyperglycemic agent-1 (compound 10) is a potent *α-Glucosidase* inhibitor, with an IC₅₀ of 0.53 μM. Anti-hyperglycemic agent-1 can be used for diabetes research .

HY-B0141AS1

Alpha-Estradiol-d2 Alfatradiol-d₂; Epiestradiol-d₂; Epiestrol-d₂	5 alpha Reductase Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia .

HY-N15613

*α-Synuclein inhibitor* 14**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 14 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia officinarum. α-Synuclein inhibitor 14 can inhibit the aggregation of *α-synuclein, with an inhibition rate of 72.4% at a concentration of 10 μM. α-Synuclein inhibitor* 14 can be used in the research of neurodegenerative diseases such as Parkinson's disease .

HY-U00090

N-Methylmoranoline MOR 14; N-Methyl-1-deoxynojirimycin; N-Methylmoranolin	Glycosidase	Metabolic Disease
N-Methylmoranoline (MOR 14) is an *α-glucosidase* inhibitor.

HY-175308

*α-Synuclein inhibitor* 15**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 15 (Compound 1) is an inhibitor targeting the fibrillation growth of *α-synuclein* (IC₅₀=18 μM). α-Synuclein inhibitor 15 is promising for research of neurodegenerative diseases, such as Parkinson's disease (PD) and Lewy body dementia (LBD) .

HY-173275

*PDGFRα kinase inhibitor* 3**	PDGFR	Cancer
PDGFRα kinase inhibitor 3 (Compound L7) is a highly potent inhibitor targeting the PDGFRα ^D842V kinase with IC₅₀s values of 23.8 nM and 2.1 nM in biochemical and cellular assays, respectively. PDGFRα kinase inhibitor 3 binds to the ATP-binding pocket of PDGFRα ^D842V to block its downstream signaling pathways and inhibit kinase activity. PDGFRα kinase inhibitor 3 can be used for gastrointestinal stromal tumors (GISTs) study .

HY-161262

SB03178	FAP	Cancer
SB03178 is a fibroblast activation protein-alpha (FAP) inhibitor. SB03178 can be conjugated with DOTA and can be used for cancer research .

HY-N11697

α-Cryptoxanthin	P-glycoprotein	Cancer
α-Cryptoxanthin is a natural carotenoid with anticancer effects. α-Cryptoxanthin inhibits multidrug resistance 1 (MDR1) mediated efflux pump .

HY-129113R

α-?Chaconine (Standard)	Reference Standards COX	Inflammation/Immunology
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N10426

(+)-Cembrene A	Glycosidase	Metabolic Disease
(+)-Cembrene A (Compound 5) is a *α-glucosidase* inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-121991

N-5-Carboxypentyl-1-deoxynojirimycin	Glycosidase	Others
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor, and also can be used to prepare affinity matrices for binding to resins.

HY-N8459

α-Cembrenediol α-CBD	EBV	Cancer
α-Cembrenediol is a potent inhibitor of *EBV*.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

HY-19144

ONO-3805	5 alpha Reductase	Others
ONO-3805 is an early lead compound of a non-steroidal 5α-reductase inhibitor, used to inhibit the conversion of testosterone to dihydrotestosterone, with potential effects in inhibiting benign prostatic hyperplasia.

HY-146305

α-Glucosidase-IN-4	Glycosidase	Infection Cardiovascular Disease Others Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
α-Glucosidase-IN-4 is a reversible and mixed type *α-glucosidase* inhibitor with an IC₅₀ of 12.98 μM, a K_I of 27.02 μM, and a K_IS of 13.65 μM, respectively .

HY-159649A

(1R)-BMS-986408	DGK	Cancer
(1R)-BMS-986408 is an orally active dual DGK α/ζ inhibitor that restores T cell-mediated anti-tumor immunity by enhancing T cell signaling .

HY-N7095

Ceftezole CTZ	Bacterial Antibiotic	Infection
Ceftezole (CTZ) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole (CTZ) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-105217

Turosteride FCE 26073	5 alpha Reductase	Metabolic Disease
Turosteride is a selective 5 alpha-reductase inhibitor, with IC₅₀ values of 55 and 53 nM for human and rat prostatic 5 alpha-reductases, respectively. Turosteride can reduce the prostate and seminal vesicle weights .

HY-N7763

Casuarictin	Glycosidase	Neurological Disease
Casuarictin is a potent and competitive *α-glucosidase* inhibitor with an IC₅₀ of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research .

HY-149509

*α-Synuclein inhibitor* 9**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 9 (Compound 20C) is an *α-Synuclein* inhibitor. α-Synuclein inhibitor 9 binds to cavities in mature α-synuclein fibrils and reduces the β-sheet structure. α-Synuclein inhibitor 9 inhibits A53T α-Syn aggregation. α-Synuclein inhibitor 9 has neuroprotective effect, improves brain functional connection and relieves motor dysfunction.α-Synuclein inhibitor 9 can be used for Parkinson’s disease (PD) research. .

HY-152195

*ChoKα inhibitor-5*	Apoptosis	Cancer
ChoKα inhibitor-5 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-5 can inhibit HChoK α1 with an IC₅₀ value of 0.64 μM. ChoKα inhibitor-5 also can induce apoptosis. ChoKα inhibitor-5 can be used for the research of cancer .

HY-152191

*ChoKα inhibitor-3*	Apoptosis	Cancer
ChoKα inhibitor-3 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC₅₀ value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer .

HY-162799

*ChoKα inhibitor-6*	Choline Kinase	Cancer
ChoKα inhibitor-6 (compound Fa22) is a less specific ChoKα1 inhibitor with antitumor activity .

HY-152552

*α-Synuclein inhibitor* 8**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 8 is an active inhibitor of *α-Synuclein* with an IC₅₀ value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity .

HY-147644

*α-Synuclein inhibitor* 3**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 3 (Compound 7g) is a α-synuclein (α -Syn) aggregation inhibitor. α-Synuclein inhibitor 3 can be used for Parkinson’s disease research .

HY-N8120

Bisabolone oxide A	Glycosidase	Metabolic Disease
Bisabolone oxide A is an *α-glucosidase* inhibitor .

HY-119593

α-Homonojirimycin Homonojirimycin	Glycosidase	Metabolic Disease
α-Homonojirimycin is a potent *α-glucosidase* inhibitor .

HY-163519

*α-Synuclein inhibitor* 13**	α-synuclein	Neurological Disease
α-Synuclein inhibitor 13 is an inhibitor of α-synuclein (α-Syn). α-Synuclein inhibitor 13 inhibits the aggregation of α-Syn proteins and is able to break down formed fibers. It is mainly used in Parkinson's disease research .

HY-152193

*ChoKα inhibitor-4*	Apoptosis	Cancer
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC₅₀=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression .

Cat. No.	Product Name	Type

HY-10182G

Laduviglusib 2 Publications Verification CHIR-99021; CT99021	Fluorescent Dyes
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-15244G

Alpelisib

Fluorescent Dyes

Alpelisib GMP is Alpelisib (HY-15244) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome .

Cat. No.	Product Name	Type

HY-10182G

Laduviglusib 2 Publications Verification CHIR-99021; CT99021	Biochemical Assay Reagents
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-78000

Methyl 4-formylbenzoate 4-Carbomethoxybenzaldehyde; 4-Carboxybenzaldehyde methyl ester; Terephthalaldehydic acid methyl ester; Methyl 4-formylbenzoate	Biochemical Assay Reagents
Methyl 4-formylbenzoate (4-Carbomethoxybenzaldehyde; 4-Carboxybenzaldehyde methyl ester; Terephthalaldehydic acid methyl ester; Methyl 4-formylbenzoate) is a intermediate that can be used for the synthesis of chalcone amide α-glucosidase inhibitors .

HY-78000R

Methyl 4-formylbenzoate (Standard) 4-Carbomethoxybenzaldehyde (Standard); 4-Carboxybenzaldehyde methyl ester (Standard); Terephthalaldehydic acid methyl ester (Standard); Methyl 4-formylbenzoate (Standard)	Biochemical Assay Reagents
Methyl 4-formylbenzoate (4-Carbomethoxybenzaldehyde) (Standard) is the analytical standard of Methyl 4-formylbenzoate (HY-78000). This product is intended for research and analytical applications. Methyl 4-formylbenzoate is a drug intermediate that can be used to synthesis chalcone amide α-glucosidase inhibitors .

HY-15244G

Alpelisib

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P10600A

BIMAX2 acetate	Ras	Others
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P4286

H-Gly-Leu-Phe-OH	Peptides	Cancer
H-Gly-Leu-Phe-OH (GLF), an immunostimulatory tripeptide derived from α-lactalbumin, inhibits anticancer agent Etoposide-induced alopecia, epidermal thickening, and thinning of the adipocyte layer .

HY-P5881

*PKCα (C2-4) inhibitor* peptide**	PKC	Cardiovascular Disease
PKCα (C2-4) inhibitor peptide is a PKCα specific inhibitor peptide that blocks the inhibition of I_Kr by the α_1A adrenoreceptor agonist A-61603 (HY-101366) .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Reference Standards Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-P10600

BIMAX2	Ras	Others
BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P10813

ZLIRTLHEWY	CD47	Inflammation/Immunology Cancer
ZLIRTLHEWY is a potent peptide CD47/SIRPα interaction inhibitor. ZLIRTLHEWY is promising for research of cancers .

HY-P10850

PIYLGGVFQ	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
PIYLGGVFQ is a peptide inhibitor for *TNF-α*. PIYLGGVFQ inhibits TNF-α-mediated apoptosis, NF-κB nuclear translocation and activation. PIYLGGVFQ exhibits anti-arthritic activity in the CIA mouse model .

HY-P10869

dCNP 1 Publications Verification	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology Cancer
dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9926

Dupilumab 5+ Cited Publications REGN-668; SAR-231893	Interleukin Related	Inflammation/Immunology Cancer
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis .

HY-P990211

Anti-Mouse IL-6R Antibody (15A7)	Interleukin Related	Inflammation/Immunology Cancer
Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer .

HY-P990774

Verekitug ASP-7266; TRAB-1; UPB-101	Interleukin Related	Inflammation/Immunology
Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .

HY-P990033

Anzurstobart CC-95251; BMS-986351	CD47	Cancer
Anzurstobart is a CD47/SIRPα inhibitor with human SIRPα K_d of 0.0541 nM and human SIRPα IC₅₀ of 100 nM. Anzurstobart binds SIRPα at a CD47-overlapping site, blocks CD47-SIRPα interactions, inhibits CD47-SIRPα axis signaling, and binds across 6 prevalent human SIRPα haplotypes. Anzurstobart binds SIRPγ and inhibits CD47-SIRPγ interactions. Anzurstobart can be used for the research of non-Hodgkin's lymphoma, colorectal cancer, squamous cell carcinoma of the head and neck, diffuse large B-cell lymphoma, and advanced solid and hematologic malignancies .

HY-P992021

WM-A1-3389	Transmembrane Glycoprotein	Cancer
WM-A1-3389 is an anti-human IGSF1monoclonal antibody and tumor growth inhibitor. WM-A1-3389 specifically binds to the C-terminus of IGSF1, increases secretion of Granzyme B, IFN?γ, and TNF?α, and inhibits growth of colon cancer or biliary tract cancer in xenogeneic or allogeneic mouse implantation models. WM-A1-3389 can be used for the research of colon cancer, biliary tract cancer, and head and neck cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0089

Acarbose Maximum Cited Publications 10 Publications Verification BAY g 5421	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Anti-aging Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-N6722

Swainsonine 1 Publications Verification Tridolgosir	Infection Alkaloids Piperidine Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Sphaerophysa salsula (Pall.) DC. Plants Disease Research Fields Source Classification	Apoptosis Antibiotic
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible *α-mannosidase* inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

HY-14860

1-Deoxynojirimycin 5+ Cited Publications Duvoglustat	Alkaloids Piperidine Alkaloids Classification of Application Fields Metabolic Disease Plants Moraceae Disease Research Fields Morus alba Linn. Source Classification	Glycosidase PI3K
1-Deoxynojirimycin (Duvoglustat) is a potent and orally active *α-glucosidase* inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-B0141A

Alpha-Estradiol Alfatradiol; Epiestradiol; Epiestrol	Monophenols Classification of Application Fields Anti-aging Disease markers Phenols Endocrine diseases Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	5 alpha Reductase Endogenous Metabolite Bacterial
Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-128754

Monoolein 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite NO Synthase Interleukin Related TNF Receptor
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as IL-12 p40, IL-6, and *TNF-α*, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

HY-N0472

Geraniin 3 Publications Verification	Phyllanthus urinaria Linn. Classification of Application Fields Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor
Geraniin is a *TNF-α* releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-N6968

α-Humulene Humulene; α-Caryophyllene	Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase COX
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression .

HY-14860A

1-Deoxynojirimycin hydrochloride 5+ Cited Publications Duvoglustat hydrochloride	Commelinaceae Classification of Application Fields Commelina communis L. Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides Source Classification	Glycosidase PI3K Bacterial Antibiotic
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active *α-glucosidase* inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-N0777

Isorhamnetin-3-O-glucoside 3 Publications Verification	Flavonols Cruciferous vegetables Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Brassicaceae Disease Research Fields Source Classification	Others PERK ERK Akt PI3K Lipase
Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity .

HY-N1200

Stigmasterol glucoside	other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	5 alpha Reductase
Stigmasterol glucoside is a sterol compound and a *5α-reductase* inhibitor with an IC₅₀ value of 27.2 µM. Stigmasterol glucoside has certain anti-inflammatory, antioxidant, and anti-tumor activities .

HY-B0025

Voglibose 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis .

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Plants Inflammation/Immunology Disease Research Fields Source Classification	COX
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and *TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N11908

α-Santalol cis-α-Santalol	Structural Classification Santalum album Linn. Terpenoids Sesquiterpenes Plants Source Classification Santalaceae	Akt Survivin Apoptosis Caspase PARP
α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus .

HY-N0419

Quercimeritrin 2 Publications Verification Quercetin-7-O-β-D-glucopyranoside	Flavonols Structural Classification Ginkgoaceae Classification of Application Fields Metabolic Disease Plants Compositae Endogenous metabolite Ginkgo biloba Human Gut Microbiota Metabolites Flavonoids Derris scandens Disease Research Fields Source Classification	Glycosidase c-Kit MMP VEGFR Aurora Kinase
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor (with an IC₅₀ of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .

HY-Y0598

trans-Chalcone 2 Publications Verification Benzylideneacetophenone	Structural Classification Flavonoids Aronia melanocarpa Rosaceae Plants	Fatty Acid Synthase (FASN) Apoptosis Fungal
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and *α-amylase* inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity .

HY-N6675

Gardenia yellow	Structural Classification Natural Products Neurological Disease Classification of Application Fields Lridaceae Plants Crocus sativus L. Disease Research Fields Source Classification Cancer	Amylases Glycosidase
Gardenia yellow is a competitive inhibitor of *α-Amylase* (HY-B2193) and *α-glucosidase. Gardenia yellow can bind to the catalytic sites of α-Amylase* and α-glucosidase, inhibit starch digestion, and significantly increase the contents of resistant starch and slowly digestible starch in starch-based systems. Gardenia yellow reduces the glycemic index and hydrolysis index. Gardenia yellow can be used in diabetes-related research .

HY-N1470

Plantagoside	Plantaginaceae Structural Classification Flavonoids Classification of Application Fields Flavonones Phenols Polyphenols Metabolic Disease Plantago asiatica L. Plants Disease Research Fields Source Classification	Glycosidase
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive *α-mannosidase* inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-125713

Ganoderic acid Y	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	Glycosidase Enterovirus
Ganoderic acid Y is a *α-glucosidase* inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating .

HY-W009417

Cedryl acetate	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Taxodiaceae Metabolic Disease Plants Cunninghamia lanceolata var. konishii Disease Research Fields Source Classification	Environmental Pollutants Glycosidase
Cedryl acetate is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Cardiovascular Disease Monophenols other families Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-W014118

α-Hexylcinnamaldehyde	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants
α-Hexylcinnamaldehyde is an O-acetyltransferase (OAT) inhibitor. α-Hexylcinnamaldehyde inhibits OAT-mediated bioactivation of nitroarene mutagens, exerts antimutagenic activity through demutagenic and bioantimutagenic mechanisms, and interferes with ATP-binding cassette (ABC) transporter function to reduce substrate efflux. α-Hexylcinnamaldehyde alters membrane permeability, fluidizes phospholipid membranes, exerts antioxidant effects, and enhances the antiproliferative effect of Doxorubicin on human cancer cells. α-Hexylcinnamaldehyde can be used in the research of colorectal adenocarcinoma, T-cell leukemia, and multidrug-resistant cancers .

HY-113062

20α-Dihydroprogesterone 20-OH-P	Animals Steroids Source Classification	Endogenous Metabolite Cytochrome P450
20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437). 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC₅₀ about 5 μM .

HY-B0141AR

Alpha-Estradiol (Standard) Alfatradiol(Standard); Epiestradiol(Standard); Epiestrol (Standard)	Structural Classification Classification of Application Fields Anti-aging Disease markers Phenols Endocrine diseases Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Reference Standards 5 alpha Reductase Endogenous Metabolite Bacterial
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol. This product is intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a *5α-reductase* inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N7377

Butyl isobutyl phthalate	Natural Products other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Glycosidase
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive *α-glucosidase* inhibitor with an IC₅₀ value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment .

HY-135530

Chinese gallotannin	Sapindaceae Phenols Polyphenols Plants Harpullia pendula Planch. ex F.Muell. Source Classification	Amylases
Chinese gallotannin is a non-specific promiscuous *α-amylase* inhibitor with a K_i of 0.82 μg/mL for human salivary α-amylase. Chinese gallotannin can be used for the research of diabetes .

HY-B0089R

Acarbose (Standard) BAY g 5421 (Standard)	Structural Classification Polysaccharides Microorganisms Saccharides Source Classification	Reference Standards Glycosidase
Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-N15497

Terpestacin	Animals Terpenoids Sesquiterpenes Source Classification	Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase
Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and *HIF-1α*. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity .

HY-14860R

1-Deoxynojirimycin (Standard) Duvoglustat (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Plants Moraceae Morus alba Linn. Source Classification	Reference Standards Glycosidase PI3K
1-Deoxynojirimycin (Standard) is the analytical standard of 1-Deoxynojirimycin. This product is intended for research and analytical applications. 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-N7683

Prunetin 5-O-β-D-glucopyranoside	Structural Classification Monophenols Flavonoids Classification of Application Fields Rosaceae Phenols Metabolic Disease Plants Prunus avium Disease Research Fields Isoflavones Source Classification	Glycosidase
Prunetin 5-O-β-D-glucopyranoside is an isoflavone. Prunetin 5-O-β-D-glucopyranoside can be isolated from the pedicels of Prunus avium and Prunus cerasus. Prunetin 5-O-β-D-glucopyranoside acts as a non-competitive *α-glucosidase* inhibitor, with a IC₅₀ of 56.05 μg/mL and a K_i of 121 μg/mL against Saccharomyces cerevisiae α-glucosidase. Prunetin 5-O-β-D-glucopyranoside can be used in studies related to type 2 diabetes .

HY-101546A

Cavidine (+)-Cavidine	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Plants Isoquinoline Alkaloids Papaveraceae Source Classification	p38 MAPK ERK Interleukin Related
Cavidine ((+)-Cavidine) is an analgesic and anti-inflammatory agent. Cavidine can be isolated from Corydalis ternata f. yanhusuo (Y.H.Chou & Chun C.Hsu) Y.C.Zhu. Cavidine reduces the expression of inflammatory factors IL-1β, IL-6 and *TNF-α*, and inhibits calcium ion influx. Cavidine inhibits the phosphorylation of p38 and ERK1/2. Cavidine increases mechanical and thermal pain thresholds in chronic pain models. Cavidine can be used for the research of chronic pain .

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Cicer arietinum L. Plants Compositae Saccharides Monosaccharides Source Classification	Glycosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active *α-glucosidase* inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

HY-N8745

α-Peltatin	Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae Source Classification	Fungal
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-N3706

Dehydro-α-lapachone	Structural Classification Catalpa ovata G. Don Bignoniaceae Plants Source Classification	Fungal
Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC₅₀ value 0.41 mg/L .

HY-N8517

Malabaricone B	Infection Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Disease Research Fields Cancer Source Classification	Glycosidase Apoptosis
Malabaricone B, a naturally occurring plant phenolic, is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities .

HY-N16575

16-Oxoserratenediol	Lycopodiaceae Triterpenes Structural Classification Terpenoids Palhinhaea cernua (L.) Vasc. et Franco Plants Source Classification	Glycosidase
16-Oxoserratenediol (Compound 11) is a serratene-type triterpenoid found in Lycopodium cernuum L.. 16-Oxoserratenediol is a *α-glucosidase* inhibitor with inhibition rate of 43.93% at 100 μM. 16-Oxoserratenediol can be used for the research of diabetes .

HY-126535

Magnoloside B	Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Plants Source Classification	Glycosidase
Magnoloside B is an *α-glucosidase* inhibitor (IC₅₀=0.69 mM), which can be obtained from Magnolia officinalis stem bark. Magnoloside B shows moderate inhibitory activity against MGC-803 and HepG2 cells. Magnoloside B has the potential to study cancer and diabetes .

HY-N3027

Soyasaponin Aa 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	PPAR Reactive Oxygen Species (ROS)
Soyasaponin Aa is a soyasaponin that can be found in soy. Soyasaponin Aa suppresses PPARγ transcriptional activity, reduces PPARγ and C/EBPα expression, inhibits adipocyte differentiation and lipid accumulation, and reduces adipogenic marker gene expression. Soyasaponin Aa reduces hydrogen peroxide-induced reactive oxygen species (ROS) production and malondialdehyde levels. Soyasaponin Aa exhibits cellular antioxidant activity. Soyasaponin Aa can be used for the research of obesity .

HY-N17254

Onjisaponin R	Triterpenes Structural Classification Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Source Classification	Amylases
Onjisaponin R is an *α-amylase* inhibitor. Onjisaponin R can be used in diabetes research .

HY-129131

Chrysin 6-C-arabinoside 8-C-glucoside	Flavonoids Rheum palmatum L. Flavones Polygonaceae Plants Source Classification	Glycosidase
Chrysin 6-C-arabinoside 8-C-glucoside is a α±-glucosidase* inhibitors* which are widely used in the study for type 2 diabetes .

HY-N1218

Stellasterol	Structural Classification Animals Steroids Source Classification	Glycosidase Bcl-2 Family
Stellasterol is a natural product. Stellasterol has high affinity towards Bcl-2 protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor .

HY-N2223

Ganoderol B Ganodermadiol	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Metabolic Disease Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	Glycosidase
Ganoderol B is a potent *α-glucosidase* inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-N10413

Diphlorethohydroxycarmalol	other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification Ishige okamurae	Glycosidase
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active *α-glucosidase* and *α-amylase* inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-N15613

*α-Synuclein inhibitor* 14**	Phenols Polyphenols Plants Tacca chantrieri Andre Taccaceae Source Classification	α-synuclein
α-Synuclein inhibitor 14 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia officinarum. α-Synuclein inhibitor 14 can inhibit the aggregation of *α-synuclein, with an inhibition rate of 72.4% at a concentration of 10 μM. α-Synuclein inhibitor* 14 can be used in the research of neurodegenerative diseases such as Parkinson's disease .

HY-N11697

α-Cryptoxanthin	Natural Products Capsicum annuum L. Solanaceae Plants Source Classification	P-glycoprotein
α-Cryptoxanthin is a natural carotenoid with anticancer effects. α-Cryptoxanthin inhibits multidrug resistance 1 (MDR1) mediated efflux pump .

HY-129113R

α-?Chaconine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Gramineae Plants Source Classification	Reference Standards COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N10426

(+)-Cembrene A	Structural Classification Animals Terpenoids Source Classification	Glycosidase
(+)-Cembrene A (Compound 5) is a *α-glucosidase* inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-N8459

α-Cembrenediol α-CBD	Natural Products Nicotiana tabacum L. Plants Solanaceae Source Classification	EBV
α-Cembrenediol is a potent inhibitor of *EBV*.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

HY-N7763

Casuarictin	Lythraceae Trapa natans L. Phenols Polyphenols Plants Source Classification	Glycosidase
Casuarictin is a potent and competitive *α-glucosidase* inhibitor with an IC₅₀ of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research .

HY-N10306

Sycosterol A	Structural Classification Animals Steroids Source Classification	α-synuclein
Sycosterol A is a sterol-based α-synuclein (α-syn) inhibitor that targets α-synuclein aggregates and inhibits α-synuclein aggregation. Sycosterol A can be used in the study of anti-neurodegenerative diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0141AS1

Alpha-Estradiol-d2
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia .

HY-10255AS1

Sunitinib-d4
Sunitinib-d₄ is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

HY-10255AS

Sunitinib-d10
Sunitinib-d₁₀ (SU 11248-d₁₀) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

HY-B0141AS

Alpha-Estradiol-d3
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-B0089S

Acarbose-d4
Acarbose-d₄ (BAY g 5421-d₄) is deuterium labeled Acarbose. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-12753AS

Debutyldronedarone-d7 hydrochloride

Debutyldronedarone-d₇ hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone . N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .

HY-W013150S

Alpidem-d14

Alpidem-d₁₄ is the deuterium labeled Alpidem (HY-W013150) . Alpidem, an anxiolytic agent, is an orally active and brain-penetrant GABAA receptor ligand, binds to α1β2γ2 subunit-containing GABAA receptors (IC₅₀ of 17 nM) over α5β2γ2 subunit-containing GABAA receptors (IC₅₀ of >10 μM). Alpidem modulates calcium-induced mitochondrial permeability transition, induces glutathione depletion and hepatocyte necrosis, potentiates TNF-α toxicity, inhibits marble-burying and locomotor activity, enhances stressed rodent feeding behavior, and exerts anticonvulsant effects. Alpidem can be used for the research of anxiety, anxiety disorders, and convulsions.

HY-W778057

Ethyl 3,4-Dihydroxybenzoate-13C3

Ethyl 3,4-Dihydroxybenzoate- ¹³C₃ (Protocatechuic acid ethyl ester- ¹³C₃) is the ¹³C-labeled Ethyl 3,4-dihydroxybenzoate (HY-W016409). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

HY-W749516

Voglibose-13C3

Voglibose- ¹³C₃ is the ¹³C-labeled Voglibose (HY-B0025). Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

Cat. No.	Product Name		Classification

HY-128754

Monoolein 1 Publications Verification		Emulsifiers
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as IL-12 p40, IL-6, and *TNF-α*, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10182G

Laduviglusib 2 Publications Verification CHIR-99021; CT99021	GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-15244G

Alpelisib	PI3K Apoptosis	Cancer
Alpelisib GMP is Alpelisib (HY-15244) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome .

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