Decussatin 

Decussatin is an α-Amylases inhibitor isolated from the Tibetan medicinal plant Swertia mussotii. By inhibiting the catalytic activity of α-Amylases, Decussatin reduces the hydrolysis of complex carbohydrates such as starch and the intestinal absorption of glucose, thereby lowering blood glucose levels in the body. Decussatin shows no significant in vitro antibacterial or antifungal activity. Decussatin can be used for the research of type 2 diabetes^[1][2][3].

Decussatin (8 mg/mL) shows no significant inhibitory activity against Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus in in vitro antibacterial assays^[2].
Decussatin exhibits an inhibition rate of 78.0% against α-amylase at a concentration of 1 mg/mL, and its inhibitory activity at this concentration is superior to that of Acarbose (HY-B0089) at the same concentration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

The crude hydromethanolic extract of Anthocleista vogelii-the source plant for Decussatin administration at 1 g/kg via oral gavage, once daily for 7 days-significantly reduces blood glucose levels in alloxan-induced diabetic albino Wistar rats. The stem bark extract achieves a peak blood glucose reduction rate of 69.68% on day 5, while the leaf extract reaches a peak reduction rate of 60.35% on day 7; both are more effective in lowering blood glucose than Glibenclamide (HY-15206)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

302.28

C₁₆H₁₄O₆

20882-69-3

O=C1C2=C(OC3=CC=C(C(OC)=C13)OC)C=C(OC)C=C2O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Alaribe C S, et al. Antimicrobial activities of hexane extract and decussatin from stembark extract of Ficus congensis[J]. International journal of molecular sciences, 2011, 12(4): 2750-2756.

  [2]. Olubomehin O O, et al. In vivo and in vitro anti-diabetic activity of extracts of Anthoclestia vogelii Planch and isolation of Decussatin, a new α-amylase inhibitor from its stem bark and leaves[J]. Nigerian Journal of Biochemistry and Molecular Biology, 2022, 37(1): 9-16.

  [3]. Jia J, et al. Preparative separation of methylswertianin, swerchirin and decussatin from the Tibetan medicinal plant Swertia mussotii using high-speed counter-current chromatography. Phytochem Anal. 2012;23(4):332-336.  [Content Brief]