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Cat. No.: HY-N18049

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Decussatin

Decussatin is an α-Amylases inhibitor isolated from the Tibetan medicinal plant Swertia mussotii. By inhibiting the catalytic activity of α-Amylases, Decussatin reduces the hydrolysis of complex carbohydrates such as starch and the intestinal absorption of glucose, thereby lowering blood glucose levels in the body. Decussatin shows no significant in vitro antibacterial or antifungal activity. Decussatin can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 20882-69-3
Formula: C₁₆H₁₄O₆
Molecular Weight:302.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Decussatin Chemical Structure

CAS No.: 20882-69-3

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Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	100 μM Compound: 3	Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay	[PMID: 18406151]

In Vitro

Decussatin (8 mg/mL) shows no significant inhibitory activity against Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus in in vitro antibacterial assays^[2].
Decussatin exhibits an inhibition rate of 78.0% against α-amylase at a concentration of 1 mg/mL, and its inhibitory activity at this concentration is superior to that of Acarbose (HY-B0089) at the same concentration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The crude hydromethanolic extract of Anthocleista vogelii-the source plant for Decussatin administration at 1 g/kg via oral gavage, once daily for 7 days-significantly reduces blood glucose levels in alloxan-induced diabetic albino Wistar rats. The stem bark extract achieves a peak blood glucose reduction rate of 69.68% on day 5, while the leaf extract reaches a peak reduction rate of 60.35% on day 7; both are more effective in lowering blood glucose than Glibenclamide (HY-15206)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 20882-69-3
Molecular Weight 302.28
Formula C₁₆H₁₄O₆
SMILES

O=C1C2=C(OC3=CC=C(C(OC)=C13)OC)C=C(OC)C=C2O
Structure Classification
- Phenols
- Monophenols
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alaribe C S, et al. Antimicrobial activities of hexane extract and decussatin from stembark extract of Ficus congensis[J]. International journal of molecular sciences, 2011, 12(4): 2750-2756.

[2]. Olubomehin O O, et al. In vivo and in vitro anti-diabetic activity of extracts of Anthoclestia vogelii Planch and isolation of Decussatin, a new α-amylase inhibitor from its stem bark and leaves[J]. Nigerian Journal of Biochemistry and Molecular Biology, 2022, 37(1): 9-16.

[3]. Jia J, et al. Preparative separation of methylswertianin, swerchirin and decussatin from the Tibetan medicinal plant Swertia mussotii using high-speed counter-current chromatography. Phytochem Anal. 2012;23(4):332-336. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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