NISC-6
NISC-6 is a novel dual Topo-IIα/Akt inhibitor. NISC-6 has inhibitory activity against various cells, such as UACC903 (IC50 = 2.5 µM) and CHL-1 (IC50 = 0.8 µM) cells. NISC-6 dose dependently induces early and late apoptosis. NISC-6 can be used for research on melanoma.
For research use only. We do not sell to patients.
- CAS No.: 2097636-49-0
- Formula: C19H18N2O2Se
- Molecular Weight:385.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHL-1 | IC50 |
0.8 μM
Compound: 4d; NISC-6
|
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay
|
[PMID: 28458134] |
| CHL-1 | IC50 |
1.5 μM
Compound: 4d; NISC-6
|
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 48 hrs by MTT assay
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 48 hrs by MTT assay
|
[PMID: 28458134] |
| CHL-1 | IC50 |
13.7 μM
Compound: 4d; NISC-6
|
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 24 hrs by MTT assay
Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 24 hrs by MTT assay
|
[PMID: 28458134] |
| UACC-903 | IC50 |
1.7 μM
Compound: 4d; NISC-6
|
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 72 hrs by MTT assay
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 72 hrs by MTT assay
|
[PMID: 28458134] |
| UACC-903 | IC50 |
13.4 μM
Compound: 4d; NISC-6
|
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay
|
[PMID: 28458134] |
| UACC-903 | IC50 |
2.5 μM
Compound: 4d; NISC-6
|
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay
|
[PMID: 28458134] |
Chemical Information
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CAS No. 2097636-49-0
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Molecular Weight 385.32
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Formula C19H18N2O2Se
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SMILES
O=C1C2=C3C(C(N1CCCCCCN=C=[Se])=O)=CC=CC3=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)