2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Autophagy Apoptosis
  3. PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis
  4. Sunitinib glucuronate

Sunitinib glucuronate  (Synonyms: SU 11248 glucuronate)

Cat. No.: HY-10255C Purity: 95.0%
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Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.

For research use only. We do not sell to patients.

CAS No. : 1818285-48-1

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Customer Review

Based on 92 publication(s) in Google Scholar

Other Forms of Sunitinib glucuronate:

Sunitinib glucuronate Related Antibodies

Top Publications Citing Use of Products

92 Publications Citing Use of MCE Sunitinib glucuronate

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RT-PCR
IHC
Cell Proliferation/Viability Assay
IF

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522.

    Sunitinib (0-100 μM; 72 h) induces significant cell death in T98G cells.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522.

    Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522.

    Sunitinib (3 μM; 24 h) increases the expression of γ-H2Ax and Temozolomide (TMZ; 10 μM; 24 h) increases the induction of Sunitinib, in T98G cells.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.  [Abstract]

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355.  [Abstract]

    Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Western blot analysis of UCP1 protein expression level in mouse brown adipose.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2018 Nov:37:344-355.  [Abstract]

    Sutent (Sunitinib Malate) treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. Representative images of immunohistochemistry stainining of UCP1 in BAT.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 15;8(67):111110-111118.  [Abstract]

    In cell EC50 determination of CHMFL-KIT-031 with parental Colo320DM (KIT wt) and KIT V559D overexpressed Colo320DM cells.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134.  [Abstract]

    Abemaciclib causes increased PARP cleavage in RCC. In 786-O cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 27;8(56):95116-95134.  [Abstract]

    Abemaciclib causes increased PARP cleavage in RCC. In Caki-1 cells Abemaciclib exposure results in increased PARP cleavage. This effect is more rapid and pronounced when Abemaciclib is combined with Sunitinib.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: J Med Chem. 2016 Sep 22;59(18):8456-72.  [Abstract]

    Effect of compounds 1 (Imatinib), 2 (Sunitinib), and 35 on cKIT mediated signaling pathways in GIST-T1 and GIST-5R cancer cell lines.

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81.  [Abstract]

    The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by Western blot (with GAPDH as internal control).

    Sunitinib glucuronate purchased from MedChemExpress. Usage Cited in: Int J Clin Exp Pathol. 2015 Apr 1;8(4):3871-81.  [Abstract]

    The relationship between SOX9 and Raf/MEK/ERK signaling pathway. Co-treatment of si-SOX9-1 and Sorafenib (10uM, 15uM)/Sunitinib (2 uM, 3 uM) significantly decreases expression of MEK1 and its phosphorylated protein (p-MEK1/2, p-ERK1/2) as assayed by RT-PCR (with β-actin as internal control).

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    Description

    Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

    IC50 & Target[1][2]

    VEGFR2

    80 nM (IC50)

    PDGFRβ

    2 nM (IC50)

    IRE1α

     

    Molecular Weight

    592.61

    Formula

    C28H37FN4O9
    CAS No.
    Appearance

    Solid

    Color

    Orange to red

    SMILES

    O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O.O=C(/C(C1=C2)=C\C3=C(C(C(NCCN(CC)CC)=O)=C(N3)C)C)NC1=CC=C2F
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Purity & Documentation
    References
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    Sunitinib glucuronate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sunitinib glucuronate1818285-48-1SU 11248 glucuronatePDGFRVEGFRIRE1MitophagyAutophagyApoptosisPlatelet-derived growth factor receptorVascular endothelial growth factor receptorInositol requiring enzyme 1Mitochondrial AutophagyInhibitorinhibitorinhibit

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