1. Immunology/Inflammation
  2. Interleukin Related
  3. SP4206

SP4206 

Cat. No.: HY-119424
Handling Instructions

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM).

For research use only. We do not sell to patients.

SP4206 Chemical Structure

SP4206 Chemical Structure

CAS No. : 515846-21-6

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Description

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM)[1].

IC50 & Target

IL-2/IL-2Rα interaction[1]

In Vitro

SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC50s of 68.8, 80.1, 117.0, and 10.4 nM, respectively[1].

Molecular Weight

662.56

Formula

C₃₀H₃₇Cl₂N₇O₆

CAS No.

515846-21-6

SMILES

O=C(C1=CC=C(COC2=CC=C(C3=NN(C)C(C4CCN(C(CNC([[email protected]@H](CC(C)C)NC(N)=N)=O)=O)CC4)=C3)C(Cl)=C2Cl)O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SP4206SP 4206SP-4206Interleukin RelatedILIL-2IL-2RproteininteractionPPIInhibitorinhibitorinhibit

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