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DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.

For research use only. We do not sell to patients.

DS01080522 Chemical Structure

DS01080522 Chemical Structure

CAS No. : 2832159-84-7

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Description

DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation)[1]

In Vitro

DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NIH/3T3 cells
Concentration: 1-10 μM
Incubation Time: 30 min
Result: Dose-dependently decreased the phosphorylation level of CREB which is a marker of intracellular PRAKACA inhibitory activity in NIH/3T3 cells with an IC50 value of 66 nM.
Molecular Weight

471.34

Formula

C23H20Cl2N4O3

CAS No.
SMILES

O=C(N[C@H]([C@@]1([H])C[C@H](O)CN1)C2=CC(Cl)=C(C#N)C=C2)C3=CC4=CC=NC(Cl)=C4C=C3OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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DS01080522 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DS01080522
Cat. No.:
HY-150073
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