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  4. CK147

CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC50 of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection.

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CK147

CK147 Chemical Structure

CAS No. : 1883356-12-4

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CK147 Related Antibodies

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Description

CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC50 of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection[1][2].

In Vitro

CK147 (0.01-100 μM; 18 h) potently down-modulates human CD4 expression in transiently transfected HEK293T cells with an IC50 of 0.04 μM, achieving 95% maximum reduction[1].
CK147 (0.01-100 μM; 72 h) is cytotoxic to HEK293T cells with a CC50 of 0.36 μM, significantly reducing cell proliferation after 72 hours of treatment[1].
CK147 (0.01-100 μM; 72 h) inhibits proliferation of wild-type HCT116 cells with a CC50 of 0.48 μM, but has no effect on proliferation of CK147-resistant HCT116 clones, which have CC50 values >50 μM[1].
CK147 is the most potent identified CADA analog, down-modulating CD4 expression with an IC50 of 0.058 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CK147 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human embryonic kidney (HEK) 293T cells
Concentration: 0.01, 0.1, 1, 10 and 100 μM
Incubation Time: 72 h
Result: Reduces HEK293T cell proliferation in a concentration-dependent manner, with a cytotoxic concentration (CC50) of 0.36 μM.
Reduces proliferation to ≤ 10% of DMSO control levels at concentrations ≥ 0.1 μM.

Cell Proliferation Assay[1]

Cell Line: wild-type and CK147-resistant HCT116 human colon cancer cells
Concentration: 0.01, 0.1, 1, 10 and 100 μM
Incubation Time: 72 h
Result: Inhibits proliferation of wild-type HCT116 cells, with a CC50 of 0.48 μM.
Shows no effect on proliferation of three CK147-resistant HCT116 clones (10, 13, 16), which have CC50 values > 50 μM and proliferation remaining near 100% of DMSO control across all tested concentrations.
Molecular Weight

616.88

Formula

C32H48N4O4S2
CAS No.
SMILES

O=S(C1=CC=C(N(C)C)C=C1)(N2CC(CN(S(=O)(C3=CC=C(C)C=C3)=O)CCCN(CC4CCCCC4)CCC2)=C)=O
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References
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CK147 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK1471883356-12-4CK 147CK-147HIVHuman immunodeficiency virusCD4HCT116 cellsSec61α channelSec61α transloconprotein translocationcotranslational translocationplug helixHEK293T cellslateral gate helicesInhibitorinhibitorinhibit

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