2. Stem Cell/Wnt Others Autophagy PI3K/Akt/mTOR
  3. Wnt Autophagy Reference Standards GSK-3 Organoid β-catenin
  4. Laduviglusib (Standard)

Laduviglusib (Standard)  (Synonyms: CHIR-99021 (Standard); CT99021 (Standard))

Cat. No.: HY-10182R Purity: 99.52%
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Laduviglusib (Standard) is the analytical standard of Laduviglusib. Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

For research use only. We do not sell to patients.

Laduviglusib (Standard)

Laduviglusib (Standard) Chemical Structure

CAS No. : 252917-06-9

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Based on 1 publication(s) in Google Scholar

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

465.34

Formula

C22H18Cl2N8
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Laduviglusib (Standard) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laduviglusib (Standard)252917-06-9CHIR-99021 (Standard)CT99021 (Standard)WntAutophagyReference StandardsGSK-3Organoidβ-cateninGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninGMPWnt/β-cateninES cellES-D3 celladipogenesisGI injuryInhibitorinhibitorinhibit

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