1. Metabolic Enzyme/Protease
    Apoptosis
    Anti-infection
  2. Fatty Acid Synthase (FASN)
    Apoptosis
    Fungal
  3. trans-Chalcone

trans-Chalcone 

Cat. No.: HY-Y0598
Handling Instructions

trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity.

For research use only. We do not sell to patients.

trans-Chalcone Chemical Structure

trans-Chalcone Chemical Structure

CAS No. : 614-47-1

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Description

trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3].

In Vitro

trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM[2].
trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells[1].
trans-Chalcone (30.23-98.03 μM; 24 hours) reduces the expression of the apoptosis-related protein Bcl-2 and induces the expression of the CIDEA gene[1].
trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours[1].
trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC20=30.23 μM; IC50=58.25 μM; IC80=98.03 μM). trans-Chalcone (48 h) has IC50s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MCF-7 cell
Concentration: 30.23, 58.25, 98.03 μM
Incubation Time: 24 hours
Result: Induced apoptosis of the breast cancer cell line.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cell
Concentration: 30.23, 58.25, 98.03 μM
Incubation Time: 24 hours
Result: Caused cell cycle arrest in G1.

Western Blot Analysis[1]

Cell Line: MCF-7 cell
Concentration: 20, 40, 80 μM
Incubation Time: 24, 48 hours
Result: Reduced the expression of the apoptosis-related protein Bcl-2 and induced the expression of the CIDEA gene.
There was marked degradation of cyclin D1 at 48 h.

RT-PCR[1]

Cell Line: MCF-7 cell
Concentration: 58.25 μM
Incubation Time: 6, 24 hours
Result: Had greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours.
Molecular Weight

208.26

Formula

C₁₅H₁₂O

CAS No.

614-47-1

SMILES

O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

trans-ChalconeFatty Acid Synthase (FASN)ApoptosisFungalα-amylasecyclearrestbreastcancerMCF-7Bcl-2CIDEAAPAF1BAXInhibitorinhibitorinhibit

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