(E/Z)-BIO-acetoxime
Based on 1 Customer Validation
(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM).
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- Reinheit : 99%
- CAS. Nr.: 740841-15-0
- Formel: C18H12BrN3O3
- Molecular Weight:398.21
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
GSK-3α 10 nM (IC50) |
GSK-3β 10 nM (IC50) |
Cdk5/p25 2.4 μM (IC50) |
CDK2/cyclinA 4.3 μM (IC50) |
CDK1/cyclinB 63 μM (IC50) |
In Vitro
E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC50s of 0.01, 2.4, 4.3 and 63 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 740841-15-0
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Appearance Solid
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Molecular Weight 398.21
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Formel C18H12BrN3O3
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Color Purple to purplish red
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SMILES
CC(O/N=C1/C(NC2=C1C=CC=C2)=C3C(NC4=C\3C=CC(Br)=C4)=O)=O
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Synonyms
GSK-3 Inhibitor X
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(E/Z)-BIO-acetoxime Related Classifications
HY-114903 Related Classifications
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